Table 2.

Early pro-B cells can reconstitute T as well as B lymphoid lineages in vivo

CD45.1+, IgM+ B cells (×103)* recoveredCD45.1+CD4+ or CD8+ T cells (×103)†recovered
Day 14Day 21Day 14Day 21
Experiment 1 850, 340 850, 450 17 000, 1500 <100, 15 000 
Experiment 2 120, <100 140, 160 6100, <100 13 000, 40 000 
CD45.1+, IgM+ B cells (×103)* recoveredCD45.1+CD4+ or CD8+ T cells (×103)†recovered
Day 14Day 21Day 14Day 21
Experiment 1 850, 340 850, 450 17 000, 1500 <100, 15 000 
Experiment 2 120, <100 140, 160 6100, <100 13 000, 40 000 

There were fewer than 105 CD45.1+ cells per organ in uninjected control mice (data not shown).

*

B-cell reconstitution was determined by the presence of CD45.1+ IgM+ cells in the spleen.

†

T-cell reconstitution was determined by the presence of CD45.1+ CD4+ cells or CD45+CD8+ cells in the thymus.

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