Table 1. Mutations in the immunoglobulin... | American Society of Hematology

Table 1.

Mutations in the immunoglobulin promoter, intronic Eμ enhancer, and complete coding region of 3 Hodgkin disease-derived cell lines

Cell lines	Somatic mutations							Coding capacity	Family
	Promoter		Leader	VH region		Eμ enhancer
	Octamer motif	TATA box	Leader and intron	FW^*	CDR^†	ATTTGCGT 5′octamer	ATTTTCAT 3′octamer
L1236	1	0	4	33	18	0	0	+	VH-1
KM-H2	0	0	18	30	13	0	0	+	VH-3
L428	0	0	6	29	10	0	0	+	VH-5

Cell lines	Somatic mutations							Coding capacity	Family
	Promoter		Leader	VH region		Eμ enhancer
	Octamer motif	TATA box	Leader and intron	FW^*	CDR^†	ATTTGCGT 5′octamer	ATTTTCAT 3′octamer
L1236	1	0	4	33	18	0	0	+	VH-1
KM-H2	0	0	18	30	13	0	0	+	VH-3
L428	0	0	6	29	10	0	0	+	VH-5

Number of mutations in all framework regions.

Number of mutations in CDR1 and CDR2.