Table 1.

Number of patients and controls, sex- and age-adjusted odds ratios and 95% confidence intervals, for methylenetetrahydrofolate reductase 677 (MTHFR677), MTHFR1298, and methionine synthase 2956

GenotypePatients n = 98Controls n = 243OR95% CIP value
MTHFR 677      
 CC 45 (45.9%) 81 (33.3%) 1.00 Reference  
 CT 39 (39.8%) 126 (51.9%) 0.62 0.37-1.05 .366 
 TT 14 (14.3%) 36 (14.8%) 0.71 0.34-1.49 .076 
 CT/TT 53 (54.1%) 162 (66.7%) 0.64 0.39-1.05 .078 
MTHFR 1298*      
 AA 62 (63.3%) 159 (65.4%) 1.00 Reference  
 AC 34 (34.7%) 75 (30.8%) 1.25 0.75-2.10 .391 
 CC 1 (1.0%) 9 (3.7%) 0.30 0.38-2.45 .233 
 AC/CC 35 (35.7%) 84 (33.8%) 1.14 0.69-1.89 .611 
MS2756†      
 AA 63 (64.3%) 156 (64.2%) 1.00 Reference  
 AG 26 (26.5%) 81 (33.3%) 0.81 0.47-1.41 .461 
 GG 7 (7.2%) 6 (2.5%) 3.59 1.11-11.5 .032 
GenotypePatients n = 98Controls n = 243OR95% CIP value
MTHFR 677      
 CC 45 (45.9%) 81 (33.3%) 1.00 Reference  
 CT 39 (39.8%) 126 (51.9%) 0.62 0.37-1.05 .366 
 TT 14 (14.3%) 36 (14.8%) 0.71 0.34-1.49 .076 
 CT/TT 53 (54.1%) 162 (66.7%) 0.64 0.39-1.05 .078 
MTHFR 1298*      
 AA 62 (63.3%) 159 (65.4%) 1.00 Reference  
 AC 34 (34.7%) 75 (30.8%) 1.25 0.75-2.10 .391 
 CC 1 (1.0%) 9 (3.7%) 0.30 0.38-2.45 .233 
 AC/CC 35 (35.7%) 84 (33.8%) 1.14 0.69-1.89 .611 
MS2756†      
 AA 63 (64.3%) 156 (64.2%) 1.00 Reference  
 AG 26 (26.5%) 81 (33.3%) 0.81 0.47-1.41 .461 
 GG 7 (7.2%) 6 (2.5%) 3.59 1.11-11.5 .032 

OR indicates odds ratio; CI, confidence interval; MS, methionine synthase; PCR, polymerase chain reaction.

*

One patient (1.0%) was excluded from analysis because DNA was not amplified by PCR.

†

Two patients (2.0%) were excluded from analysis because DNA was not amplified by PCR.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal