Ki values of MMP inhibitors used in this study
| . | BB94 . | RS-11 . | RS-16 . |
|---|---|---|---|
| MMP-1 | 0.4 | 70 | 110 |
| MMP-13 | 0.53 | 0.17 | 0.87 |
| MMP-2 | 0.15 | 0.054 | 0.11 |
| MMP-9 | 0.46 | 0.065 | 0.66 |
| MMP-3 | 2.3 | 5.2 | 2.6 |
| MMP-7 | 0.44 | 240 | 570 |
| MMP-12 | 0.33 | 0.033 | ND |
| TACE | 150* | > 10 000* | 94* |
| . | BB94 . | RS-11 . | RS-16 . |
|---|---|---|---|
| MMP-1 | 0.4 | 70 | 110 |
| MMP-13 | 0.53 | 0.17 | 0.87 |
| MMP-2 | 0.15 | 0.054 | 0.11 |
| MMP-9 | 0.46 | 0.065 | 0.66 |
| MMP-3 | 2.3 | 5.2 | 2.6 |
| MMP-7 | 0.44 | 240 | 570 |
| MMP-12 | 0.33 | 0.033 | ND |
| TACE | 150* | > 10 000* | 94* |
The Ki values are determined as described in “Materials and methods” and are expressed in nM.
ND indicates not determined.
Cell-based assay, not comparable with the Kivalues of the other MMPs.