Toxicities of R115777 related to dose level
| Dose (no. patients) . | 100 mg (6) . | 300 mg (5) . | 600 mg (8) . | 900 mg (11) . | 1200 mg (4) . |
|---|---|---|---|---|---|
| Fatigue | 2 (grade 1) | 1 (grade 1) | 2 (grade 1-2) | 2 (grade 2) | |
| Neurologic | |||||
| Visual | 1 (grade 1) | ||||
| Confusion | 2 (grade 1) | 2 (grade 3) | |||
| Ataxia | 1 (grade 3) | ||||
| Neuropathy | 2 (grade 1) | ||||
| Headache | 2 (grade 1) | ||||
| Renal/endocrine | |||||
| Polydipsia | 2 (grade 1) | 4 (grade 2) | |||
| Creatinine | 2 (grade 1) | 4 (grade 1-2) | |||
| Gastrointestinal | |||||
| Nausea | 1 (grade 1) | 2 (grade 1) | 3 (grade 2) | 3 (grade 2) | |
| Vomiting | 2 (grade 1) | 1 (grade 2) | |||
| Neutropenia < 500/mm3 | 2 | 5 | |||
| Fever/infection | 1 (grade 2) | 3 (grade 2) |
| Dose (no. patients) . | 100 mg (6) . | 300 mg (5) . | 600 mg (8) . | 900 mg (11) . | 1200 mg (4) . |
|---|---|---|---|---|---|
| Fatigue | 2 (grade 1) | 1 (grade 1) | 2 (grade 1-2) | 2 (grade 2) | |
| Neurologic | |||||
| Visual | 1 (grade 1) | ||||
| Confusion | 2 (grade 1) | 2 (grade 3) | |||
| Ataxia | 1 (grade 3) | ||||
| Neuropathy | 2 (grade 1) | ||||
| Headache | 2 (grade 1) | ||||
| Renal/endocrine | |||||
| Polydipsia | 2 (grade 1) | 4 (grade 2) | |||
| Creatinine | 2 (grade 1) | 4 (grade 1-2) | |||
| Gastrointestinal | |||||
| Nausea | 1 (grade 1) | 2 (grade 1) | 3 (grade 2) | 3 (grade 2) | |
| Vomiting | 2 (grade 1) | 1 (grade 2) | |||
| Neutropenia < 500/mm3 | 2 | 5 | |||
| Fever/infection | 1 (grade 2) | 3 (grade 2) |