Patient characteristics and results of methylation-specific polymerase chain reaction
| . | MGUS . | . | Multiple myeloma . | . |
|---|---|---|---|---|
| Number of patients | 33 | 33 | ||
| Sex ratio | 1.06 | 2 | ||
| Median age (years) | 59 (43-80) | 64 (39-83) | ||
| Median time from diagnosis to MS-PCR (months) | 0 (0-246) | 8 (0-156) | ||
| Median percent of plasma cell in bone marrow | 1.5 (1-8) | 19 (1-86) | ||
| Monoclonal component isotype | ||||
| IgG | 26 | 22 | ||
| IgA | 6 | 7 | ||
| Other | 1 | 4 | ||
| Light chain of the monoclonal protein | ||||
| Kappa | 22 | 27 | ||
| Lambda | 11 | 6 | ||
| Deletion of chromosome 13 | 2/21 | 7/17 |
| . | MGUS . | . | Multiple myeloma . | . |
|---|---|---|---|---|
| Number of patients | 33 | 33 | ||
| Sex ratio | 1.06 | 2 | ||
| Median age (years) | 59 (43-80) | 64 (39-83) | ||
| Median time from diagnosis to MS-PCR (months) | 0 (0-246) | 8 (0-156) | ||
| Median percent of plasma cell in bone marrow | 1.5 (1-8) | 19 (1-86) | ||
| Monoclonal component isotype | ||||
| IgG | 26 | 22 | ||
| IgA | 6 | 7 | ||
| Other | 1 | 4 | ||
| Light chain of the monoclonal protein | ||||
| Kappa | 22 | 27 | ||
| Lambda | 11 | 6 | ||
| Deletion of chromosome 13 | 2/21 | 7/17 |
| . | . | Stage . | ||
|---|---|---|---|---|
| I/II . | III . | Relapsed or refractory . | ||
| Methylation of: | ||||
| p16INK4a | 6/31 (19%) | 1/6 (16.5%) | 3/19 (16%) | 2/5 (40%) |
| p15INK4b | 12/33 (36%) | 2/6 (33%) | 4/18 (22%) | 1/5 (20%) |
| p16INK4a andp15INK4b | 2/31 (6.5%) | 0/6 (0%) | 2/18 (11%) | 1/5 (25%) |
| . | . | Stage . | ||
|---|---|---|---|---|
| I/II . | III . | Relapsed or refractory . | ||
| Methylation of: | ||||
| p16INK4a | 6/31 (19%) | 1/6 (16.5%) | 3/19 (16%) | 2/5 (40%) |
| p15INK4b | 12/33 (36%) | 2/6 (33%) | 4/18 (22%) | 1/5 (20%) |
| p16INK4a andp15INK4b | 2/31 (6.5%) | 0/6 (0%) | 2/18 (11%) | 1/5 (25%) |
MGUS indicates monoclonal gammopathy of undetermined significance; MS-PCR, methylation-specific polymerase chain reaction; IgG, immunoglobulin G.