Cumulative drug doses in the treatment protocols for acute myeloid leukemia
| Drug . | Ara-C . | DNR . | Adria . | Amsa . | Ida . | VP16 . | Mitox . | Pred . | 6TG . | VCR . | CP . | CsA . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Induction | ||||||||||||
| HOVON 4/4A | 13 400 | 135 | 360 | 500 | 50 | |||||||
| HOVON 29 | 13 400 | 360 | 36 | 500 | 50 | |||||||
| DCLSG ANLL87* | 22 400 | 180 | 120 | 1050 | 1120 | 2580 | 6 | 1000 | ||||
| DCLSG ANLL94* | 33 400 | 120 | 36 | 950 | 20 | 1120 | 2520 | 6 | 1000 | |||
| Reinduction | ||||||||||||
| EORTC 9 | 6000 | 90 | 50 | |||||||||
| HOVON 30 | 500 | 50 | ±5 mg/kg |
| Drug . | Ara-C . | DNR . | Adria . | Amsa . | Ida . | VP16 . | Mitox . | Pred . | 6TG . | VCR . | CP . | CsA . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Induction | ||||||||||||
| HOVON 4/4A | 13 400 | 135 | 360 | 500 | 50 | |||||||
| HOVON 29 | 13 400 | 360 | 36 | 500 | 50 | |||||||
| DCLSG ANLL87* | 22 400 | 180 | 120 | 1050 | 1120 | 2580 | 6 | 1000 | ||||
| DCLSG ANLL94* | 33 400 | 120 | 36 | 950 | 20 | 1120 | 2520 | 6 | 1000 | |||
| Reinduction | ||||||||||||
| EORTC 9 | 6000 | 90 | 50 | |||||||||
| HOVON 30 | 500 | 50 | ±5 mg/kg |
(Total cumulative dose in mg/m2.) Ara-C indicates cytosine arabinoside; Adria, adriamycin; DNR, daunorubicin; Amsa, amsacrine; Ida, idarubicin; VP16, etoposide; Mitox, mitoxantrone; Pred, prednisolone; 6TG, 6-thioguanine; VCR, vincristine; CP, cyclophosphamide; and CsA, cyclosporin A.
Indicates + 5× intrathecal Ara-C.