Significance of various patient characteristics in predicting survival in patients with B-CLL
| Variable . | Coef . | Hazard ratio . | Lower .95 . | Upper .95 . | SE (coef) . | P . |
|---|---|---|---|---|---|---|
| Rai I | 0.721 | 2.056 | 0.789 | 5.354 | 0.488 | .1401 |
| Rai II | 1.217 | 3.378 | 1.198 | 9.523 | 0.529 | .0213 |
| Rai III | 1.954 | 7.057 | 1.978 | 25.179 | 0.649 | .0026 |
| Rai IV | 1.820 | 6.173 | 2.426 | 15.709 | 0.477 | .0001 |
| Lymph node involvement | 0.906 | 2.475 | 1.203 | 5.092 | 0.368 | .0138 |
| Binet A + B | 0.644 | 1.905 | 0.896 | 4.051 | 0.385 | .0940 |
| Binet C | 1.452 | 4.271 | 2.265 | 8.053 | 0.324 | .0001 |
| Prior therapy | 1.573 | 4.819 | 2.719 | 8.543 | 0.292 | .0001 |
| Gender | 0.251 | 1.285 | 0.731 | 2.262 | 0.288 | .3838 |
| Hepatomegaly | 0.473 | 1.605 | 0.678 | 3.803 | 0.440 | .2820 |
| Splenomegaly | 0.643 | 1.901 | 1.026 | 3.523 | 0.315 | .0412 |
| Hemoglobin | − 0.306 | 0.737 | 0.667 | 0.813 | 0.051 | .0001 |
| WBC | 0.004 | 1.004 | 1.002 | 1.006 | 0.001 | .0010 |
| β2M | 0.258 | 1.295 | 1.168 | 1.436 | 0.053 | .0001 |
| Marrow cellularity | 0.010 | 1.010 | 0.991 | 1.029 | 0.010 | .3134 |
| % marrow lymphocytes | 0.011 | 1.011 | 0.980 | 1.042 | 0.016 | .4967 |
| Age | 0.044 | 1.045 | 1.017 | 1.074 | 0.014 | .0018 |
| Peripheral blood lymphocytes | 0.007 | 1.007 | 1.001 | 1.014 | 0.003 | .0178 |
| CD38 | 0.015 | 1.015 | 1.007 | 1.023 | 0.004 | .0001 |
| Variable . | Coef . | Hazard ratio . | Lower .95 . | Upper .95 . | SE (coef) . | P . |
|---|---|---|---|---|---|---|
| Rai I | 0.721 | 2.056 | 0.789 | 5.354 | 0.488 | .1401 |
| Rai II | 1.217 | 3.378 | 1.198 | 9.523 | 0.529 | .0213 |
| Rai III | 1.954 | 7.057 | 1.978 | 25.179 | 0.649 | .0026 |
| Rai IV | 1.820 | 6.173 | 2.426 | 15.709 | 0.477 | .0001 |
| Lymph node involvement | 0.906 | 2.475 | 1.203 | 5.092 | 0.368 | .0138 |
| Binet A + B | 0.644 | 1.905 | 0.896 | 4.051 | 0.385 | .0940 |
| Binet C | 1.452 | 4.271 | 2.265 | 8.053 | 0.324 | .0001 |
| Prior therapy | 1.573 | 4.819 | 2.719 | 8.543 | 0.292 | .0001 |
| Gender | 0.251 | 1.285 | 0.731 | 2.262 | 0.288 | .3838 |
| Hepatomegaly | 0.473 | 1.605 | 0.678 | 3.803 | 0.440 | .2820 |
| Splenomegaly | 0.643 | 1.901 | 1.026 | 3.523 | 0.315 | .0412 |
| Hemoglobin | − 0.306 | 0.737 | 0.667 | 0.813 | 0.051 | .0001 |
| WBC | 0.004 | 1.004 | 1.002 | 1.006 | 0.001 | .0010 |
| β2M | 0.258 | 1.295 | 1.168 | 1.436 | 0.053 | .0001 |
| Marrow cellularity | 0.010 | 1.010 | 0.991 | 1.029 | 0.010 | .3134 |
| % marrow lymphocytes | 0.011 | 1.011 | 0.980 | 1.042 | 0.016 | .4967 |
| Age | 0.044 | 1.045 | 1.017 | 1.074 | 0.014 | .0018 |
| Peripheral blood lymphocytes | 0.007 | 1.007 | 1.001 | 1.014 | 0.003 | .0178 |
| CD38 | 0.015 | 1.015 | 1.007 | 1.023 | 0.004 | .0001 |