Table 1. Therapy courses . Drug . Dose .... | American Society of Hematology

Table 1.

Therapy courses

	Drug	Dose	Day
	Drug	Dose	1	2	3	4	5
Prephase V^*	Prednisone, orally/iv	30 mg/m²	x	x	x	x	x
	Cyclophosphamide, iv, 1 h	200 mg/m²	x	x	x	x	x
Course A	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Ifosfamide, iv, 1 h	800 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^†	500 mg/m²	x
	Methotrexate, it^‡	12 mg	x
	Cytarabine, it^‡	30 mg	x
	Prednisolone, it^‡	10 mg	x
	Cytarabine, iv, 1 h	150 mg/m²				x x^1-153	x x^1-153
	Etoposide, iv, 1 h	100 mg/m²				x	x
Course B	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Cyclophosphamide, iv, 1 h	200 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^†	500 mg/m²	x
	Methotrexate, it^‡	12 mg	x
	Cytarabine, it^‡	30 mg	x
	Prednisolone, it^‡	10 mg	x
	Doxorubicin, iv, 1 h	25 mg/m²				x	x
Course AA	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Ifosfamide, iv, 1 h	800 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^1-155	5 g/m²	x
	Methotrexate, it^‡	6 mg	x				x
	Cytarabine, it^‡	15 mg	x				x
	Prednisolone, it^‡	5 mg	x				x
	Vincristine, iv	1.5 mg/m²^1-154	x
	Cytarabine, iv, 1 h	150 mg/m²				x x^1-153	x x^1-153
	Etoposide, iv, 1 h	100 mg/m²				x	x
Course BB	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Cyclophosphamide, iv, 1 h	200 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^1-155	5 g/m²	x
	Methotrexate, it^‡	6 mg	x				x
	Cytarabine, it^‡	15 mg	x				x
	Prednisolone, it^‡	5 mg	x				x
	Vincristine, iv	1.5 mg/m²^1-154	x
	Doxorubicin, iv, 1 h	25 mg/m²				x	x
Course CC	Dexamethasone, orally/iv	20 mg/m²	x	x	x	x	x
	Vindesine, iv	3 mg/m²^1-154	x
	Cytarabine, iv, 3 h	2 g/m²	x x^1-153	x x^1-153
	Etoposide, iv, 1 h	150 mg/m²			x	x	x
	Methotrexate, it^‡	12 mg					x
	Cytarabine, it^‡	30 mg					x
	Prednisolone, it^‡	10 mg					x

	Drug	Dose	Day
	Drug	Dose	1	2	3	4	5
Prephase V^*	Prednisone, orally/iv	30 mg/m²	x	x	x	x	x
	Cyclophosphamide, iv, 1 h	200 mg/m²	x	x	x	x	x
Course A	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Ifosfamide, iv, 1 h	800 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^†	500 mg/m²	x
	Methotrexate, it^‡	12 mg	x
	Cytarabine, it^‡	30 mg	x
	Prednisolone, it^‡	10 mg	x
	Cytarabine, iv, 1 h	150 mg/m²				x x^1-153	x x^1-153
	Etoposide, iv, 1 h	100 mg/m²				x	x
Course B	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Cyclophosphamide, iv, 1 h	200 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^†	500 mg/m²	x
	Methotrexate, it^‡	12 mg	x
	Cytarabine, it^‡	30 mg	x
	Prednisolone, it^‡	10 mg	x
	Doxorubicin, iv, 1 h	25 mg/m²				x	x
Course AA	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Ifosfamide, iv, 1 h	800 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^1-155	5 g/m²	x
	Methotrexate, it^‡	6 mg	x				x
	Cytarabine, it^‡	15 mg	x				x
	Prednisolone, it^‡	5 mg	x				x
	Vincristine, iv	1.5 mg/m²^1-154	x
	Cytarabine, iv, 1 h	150 mg/m²				x x^1-153	x x^1-153
	Etoposide, iv, 1 h	100 mg/m²				x	x
Course BB	Dexamethasone, orally/iv	10 mg/m²	x	x	x	x	x
	Cyclophosphamide, iv, 1 h	200 mg/m²	x	x	x	x	x
	Methotrexate, iv, 24 h^1-155	5 g/m²	x
	Methotrexate, it^‡	6 mg	x				x
	Cytarabine, it^‡	15 mg	x				x
	Prednisolone, it^‡	5 mg	x				x
	Vincristine, iv	1.5 mg/m²^1-154	x
	Doxorubicin, iv, 1 h	25 mg/m²				x	x
Course CC	Dexamethasone, orally/iv	20 mg/m²	x	x	x	x	x
	Vindesine, iv	3 mg/m²^1-154	x
	Cytarabine, iv, 3 h	2 g/m²	x x^1-153	x x^1-153
	Etoposide, iv, 1 h	150 mg/m²			x	x	x
	Methotrexate, it^‡	12 mg					x
	Cytarabine, it^‡	30 mg					x
	Prednisolone, it^‡	10 mg					x

iv indicates intravenously; it, intrathecally; h, hour.

Amendment July 1993: cyclophosphamide day 1, 2 only, dexamethasone instead of prednisone, see text.

10% of dose within 0.5 h, 90% of dose iv over 23.5 hours, leucovorin rescue 12 mg/m² iv at hours 48 and 54.

2 hours after beginning of MTX iv infusion, doses were adjusted for children < 3 years of age.

12 hours apart.

10% of dose within 0.5 hours; 90% iv over 23.5 hours; leucovorin rescue (raceme folinic acid) iv 30 mg/m² at hour 42; 15 mg/m² at hours 48 and 54.

Maximum dose 2 mg for vincristine, 5 mg/m² for vindesine.