CD8 T cells of each phenotype that expressed granzyme A (GzmA) or perforin
| Donor group . | CD8 T cells . | CCR7+ . | CCR7− . | CD45RA+ . | CD45RA− . | CD62L+ . | CD62L− . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | |
| Healthy (n = 5) | 6 ± 2 | 27 ± 8 | 0.4 ± 0.4 | 3 ± 2 | 16 ± 7 | 69 ± 7 | 5 ± 2 | 14 ± 5 | 11 ± 6 | 63 ± 9 | 3 ± 1 | 16 ± 5 | 32 ± 3 | 84 ± 2 |
| HIV-seropositive (n = 11) | 34 ± 20 | 67 ± 20 | 1.5 ± 1.0 | 15 ± 12 | 40 ± 22 | 84 ± 9 | 40 ± 25 | 59 ± 20 | 34 ± 26 | 82 ± 6 | 19 ± 21 | 59 ± 16 | 47 ± 27 | 89 ± 8 |
| Stage A (n = 5) | 28 ± 18 | 71 ± 14 | 1.0 ± 0.9 | 14 ± 11 | 34 ± 18 | 85 ± 9 | 35 ± 20 | 55 ± 15 | 34 ± 26 | 83 ± 7 | 19 ± 18 | 58 ± 12 | 47 ± 20 | 88 ± 7 |
| Stage B (n = 4) | 35 ± 18 | 56 ± 24 | 1.7 ± 0.7 | 9 ± 4 | 41 ± 20 | 80 ± 8 | 37 ± 24 | 54 ± 21 | 27 ± 22 | 80 ± 6 | 9 ± 5 | 50 ± 10 | 43 ± 27 | 87 ± 9 |
| Stage C (n = 2) | 48 ± 21 | 81 ± 5 | 2.3 ± 0.7 | 30 ± 10 | 54 ± 24 | 91 ± 1 | 58 ± 24 | 79 ± 1 | 47 ± 24 | 86 ± 1 | 39 ± 27 | 80 ± 8 | 56 ± 34 | 94 ± 4 |
| Donor group . | CD8 T cells . | CCR7+ . | CCR7− . | CD45RA+ . | CD45RA− . | CD62L+ . | CD62L− . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | Perforin . | GzmA . | |
| Healthy (n = 5) | 6 ± 2 | 27 ± 8 | 0.4 ± 0.4 | 3 ± 2 | 16 ± 7 | 69 ± 7 | 5 ± 2 | 14 ± 5 | 11 ± 6 | 63 ± 9 | 3 ± 1 | 16 ± 5 | 32 ± 3 | 84 ± 2 |
| HIV-seropositive (n = 11) | 34 ± 20 | 67 ± 20 | 1.5 ± 1.0 | 15 ± 12 | 40 ± 22 | 84 ± 9 | 40 ± 25 | 59 ± 20 | 34 ± 26 | 82 ± 6 | 19 ± 21 | 59 ± 16 | 47 ± 27 | 89 ± 8 |
| Stage A (n = 5) | 28 ± 18 | 71 ± 14 | 1.0 ± 0.9 | 14 ± 11 | 34 ± 18 | 85 ± 9 | 35 ± 20 | 55 ± 15 | 34 ± 26 | 83 ± 7 | 19 ± 18 | 58 ± 12 | 47 ± 20 | 88 ± 7 |
| Stage B (n = 4) | 35 ± 18 | 56 ± 24 | 1.7 ± 0.7 | 9 ± 4 | 41 ± 20 | 80 ± 8 | 37 ± 24 | 54 ± 21 | 27 ± 22 | 80 ± 6 | 9 ± 5 | 50 ± 10 | 43 ± 27 | 87 ± 9 |
| Stage C (n = 2) | 48 ± 21 | 81 ± 5 | 2.3 ± 0.7 | 30 ± 10 | 54 ± 24 | 91 ± 1 | 58 ± 24 | 79 ± 1 | 47 ± 24 | 86 ± 1 | 39 ± 27 | 80 ± 8 | 56 ± 34 | 94 ± 4 |
Values are means ± SD percentages.