Characteristics of 48 men and 16 women with hereditary hemochromatosis according to homozygosity for the C282Y mutation
| Variable . | C282Y +/+ (n = 38) . | Non-C282Y +/+ (n = 26) . | P value . |
|---|---|---|---|
| Age, y | 46 ± 13 (20-69) | 52 ± 7 (36-60) | .04 |
| Transferrin saturation, % | 86 ± 14 (54-100) | 75 ± 17 (46-100) | .006 |
| Ferritin, μg/L | 2103 ± 1801 (422-8000) | 1558 ± 1281 (380-5800) | NS |
| Iron removed, g | 11.6 ± 7 (3.5-30) | 7.8 ± 5.5 (3-13.5) | .02 |
| No. (%) patients with grade IV siderosis* | 20 (53%) | 14 (54%) | NS |
| Variable . | C282Y +/+ (n = 38) . | Non-C282Y +/+ (n = 26) . | P value . |
|---|---|---|---|
| Age, y | 46 ± 13 (20-69) | 52 ± 7 (36-60) | .04 |
| Transferrin saturation, % | 86 ± 14 (54-100) | 75 ± 17 (46-100) | .006 |
| Ferritin, μg/L | 2103 ± 1801 (422-8000) | 1558 ± 1281 (380-5800) | NS |
| Iron removed, g | 11.6 ± 7 (3.5-30) | 7.8 ± 5.5 (3-13.5) | .02 |
| No. (%) patients with grade IV siderosis* | 20 (53%) | 14 (54%) | NS |
Values are mean ± SD (range) unless otherwise indicated.
NS indicates not significant.
On Perls staining.29