Admission clinical and laboratory characteristics
| Variable . | All . | Severe . | Uncomplicated . | P . |
|---|---|---|---|---|
| No. | 20 | 14 | 6 | — |
| Age, y* | 31.9 (26.0-37.8) | 29.4 (22.8-36.1) | 37.7 (22.8-52.6) | .2 |
| Body weight/kg* | 51.5 (48.9-54.1) | 51.5 (48.3-54.7) | 51.4 (45.2-57.7) | 1.0 |
| No. of times with prior malaria† | 1 (0-10) | 1 (0-10) | 0 (0-4) | .2 |
| No. of days ill† | 4.0 (1.0-8.0) | 4.5 (2.0-8.0) | 2.5 (1.0-6.0) | .1 |
| Systolic blood pressure, mmHg† | 110 (80-130) | 106 (80-125) | 110 (100-130) | .3 |
| Glasgow coma scale score, out of 15† | 15 (12-15) | 15 (12-15) | 15 (13-15) | .7 |
| Splenomegaly, cm† | 0 (0-6) | 0.5 (0-6) | 0 (0-3) | .3 |
| Hepatomegaly, cm† | 1.75 (0-10.00) | 1.75 (0-10.00) | 1.25 (0-4.00) | .8 |
| Hematocrit, %* | 40.1 (37.0-43.2) | 38.6 (34.7-42.5) | 43.7 (38.1-49.2) | .1 |
| Parasitemia, μL‡,1-153 | 283 400 (183 950-436 616) | 334 965 (184 587-607 715) | 191 911 (118 359-311 100) | .2 |
| Trophozoites and schizonts, %† | 1 (0-75) | 0 (0-69) | 11.5 (0-75) | .2 |
| Reticulocytes/μL*,1-153 | 53 160 (35 199-71 122) | 46 329 (25 830-66 827) | 69 101 (23 549-114 653) | .2 |
| RESA-RBC/μL‡,1-153 | 12 933 (9367-17 853) | 13 183 (8712-19 948) | 12 255 (5961-25 188) | .8 |
| Parasitemia:RESA-RBC ratio† | 30:1 (1:1-179:1) | 32:1 (1:1-179:1) | 22:1 (5:1-33:1) | .2 |
| Serum creatinine, μM/L* | 111 (97-126) | 114 (94-135) | 104 (93-114) | .5 |
| Serum urea, mM/L† | 7.5 (2.9-20.7) | 7.9 (4.3-20.7) | 4.6 (2.9-11.8) | .08 |
| Plasma glucose, mM/L* | 7.8 (6.1-9.4) | 7.9 (6.2-9.7) | 7.4 (2.4-12.3) | .8 |
| Plasma lactate, mM/L* | 3.6 (2.9-4.2) | 4.1 (3.3-4.8) | 2.5 (1.7-3.2) | .01 |
| Serum total bilirubin, μM/L† | 27 (4-339) | 51 (15-339) | 14 (4-34) | .006 |
| Variable . | All . | Severe . | Uncomplicated . | P . |
|---|---|---|---|---|
| No. | 20 | 14 | 6 | — |
| Age, y* | 31.9 (26.0-37.8) | 29.4 (22.8-36.1) | 37.7 (22.8-52.6) | .2 |
| Body weight/kg* | 51.5 (48.9-54.1) | 51.5 (48.3-54.7) | 51.4 (45.2-57.7) | 1.0 |
| No. of times with prior malaria† | 1 (0-10) | 1 (0-10) | 0 (0-4) | .2 |
| No. of days ill† | 4.0 (1.0-8.0) | 4.5 (2.0-8.0) | 2.5 (1.0-6.0) | .1 |
| Systolic blood pressure, mmHg† | 110 (80-130) | 106 (80-125) | 110 (100-130) | .3 |
| Glasgow coma scale score, out of 15† | 15 (12-15) | 15 (12-15) | 15 (13-15) | .7 |
| Splenomegaly, cm† | 0 (0-6) | 0.5 (0-6) | 0 (0-3) | .3 |
| Hepatomegaly, cm† | 1.75 (0-10.00) | 1.75 (0-10.00) | 1.25 (0-4.00) | .8 |
| Hematocrit, %* | 40.1 (37.0-43.2) | 38.6 (34.7-42.5) | 43.7 (38.1-49.2) | .1 |
| Parasitemia, μL‡,1-153 | 283 400 (183 950-436 616) | 334 965 (184 587-607 715) | 191 911 (118 359-311 100) | .2 |
| Trophozoites and schizonts, %† | 1 (0-75) | 0 (0-69) | 11.5 (0-75) | .2 |
| Reticulocytes/μL*,1-153 | 53 160 (35 199-71 122) | 46 329 (25 830-66 827) | 69 101 (23 549-114 653) | .2 |
| RESA-RBC/μL‡,1-153 | 12 933 (9367-17 853) | 13 183 (8712-19 948) | 12 255 (5961-25 188) | .8 |
| Parasitemia:RESA-RBC ratio† | 30:1 (1:1-179:1) | 32:1 (1:1-179:1) | 22:1 (5:1-33:1) | .2 |
| Serum creatinine, μM/L* | 111 (97-126) | 114 (94-135) | 104 (93-114) | .5 |
| Serum urea, mM/L† | 7.5 (2.9-20.7) | 7.9 (4.3-20.7) | 4.6 (2.9-11.8) | .08 |
| Plasma glucose, mM/L* | 7.8 (6.1-9.4) | 7.9 (6.2-9.7) | 7.4 (2.4-12.3) | .8 |
| Plasma lactate, mM/L* | 3.6 (2.9-4.2) | 4.1 (3.3-4.8) | 2.5 (1.7-3.2) | .01 |
| Serum total bilirubin, μM/L† | 27 (4-339) | 51 (15-339) | 14 (4-34) | .006 |