Phenotypic characteristics of Burkitt-like lymphoma and diffuse large B-cell lymphoma
| Characteristic . | BLL . | DLBCL . |
|---|---|---|
| Lineage or maturation markers | ||
| Pan B (CD19, CD20, CD22) | 100 | 100 |
| CD10 | 85 | 27 |
| Proliferation marker Ki-67 | ||
| Mean (range) percentage of positive cells | 88 (78–95) | 53 (10–95) |
| Oncogene expression | ||
| p53 | 54 | 16 |
| Bcl-2 | 15 | 53 |
| Tumor-infiltrating cytotoxic T-cells | ||
| CD8+T cells less than 6% | 80 | 24 |
| Cell adhesion molecule expression | ||
| CD11a/LFA-1α | 38 | 87 |
| CD18/LFA-1β | 10 | 85 |
| CD58/LFA-3 | 36 | 87 |
| CD54/ICAM | 42 | 85 |
| Absence of any CAM | 92 | 27 |
| Homing receptor expression | ||
| CD44 | 8 | 86 |
| Characteristic . | BLL . | DLBCL . |
|---|---|---|
| Lineage or maturation markers | ||
| Pan B (CD19, CD20, CD22) | 100 | 100 |
| CD10 | 85 | 27 |
| Proliferation marker Ki-67 | ||
| Mean (range) percentage of positive cells | 88 (78–95) | 53 (10–95) |
| Oncogene expression | ||
| p53 | 54 | 16 |
| Bcl-2 | 15 | 53 |
| Tumor-infiltrating cytotoxic T-cells | ||
| CD8+T cells less than 6% | 80 | 24 |
| Cell adhesion molecule expression | ||
| CD11a/LFA-1α | 38 | 87 |
| CD18/LFA-1β | 10 | 85 |
| CD58/LFA-3 | 36 | 87 |
| CD54/ICAM | 42 | 85 |
| Absence of any CAM | 92 | 27 |
| Homing receptor expression | ||
| CD44 | 8 | 86 |
Values are percentages of positive cases unless otherwise indicated.
LFA indicates lymphocyte function–associated antigen; ICAM, intercellular adhesion molecule; for other abbreviations, see Table 1.