Previous reports of immune thrombocytopenia caused by sensitivity to a drug metabolite
| Reference . | Implicated drug . | Ig class . | Sensitizing metabolite . |
|---|---|---|---|
| Eisner and Shahidi,251972 | Acetaminophen | IgA > IgG | Acetaminophen sulfate |
| Eisner and Kasper,26 1972 | PAS | IgG, IgA | Glycine conjugate of PAS? |
| Meyer et al,27 1993 | Ibuprofen | IgG, IgM | Unidentified urinary metabolite |
| Kiefel et al,71987 | Sulfamethoxazole | IgG | N4-acetyl sulfamethoxazole |
| Reference . | Implicated drug . | Ig class . | Sensitizing metabolite . |
|---|---|---|---|
| Eisner and Shahidi,251972 | Acetaminophen | IgA > IgG | Acetaminophen sulfate |
| Eisner and Kasper,26 1972 | PAS | IgG, IgA | Glycine conjugate of PAS? |
| Meyer et al,27 1993 | Ibuprofen | IgG, IgM | Unidentified urinary metabolite |
| Kiefel et al,71987 | Sulfamethoxazole | IgG | N4-acetyl sulfamethoxazole |
Ig indicates immunoglobulin; PAS, para-aminosalicylic acid.