Hemodynamic and microvascular parameters in trauma- and tumor necrosis factor-α–induced inflammation
| Mouse genotype . | Mice (n) . | Venules (n) . | Diameter (μm) . | Centerline velocity (μm/s) . | Wall shear rate (s−1) . | Systemic blood pressure (mmHg) . |
|---|---|---|---|---|---|---|
| Untreated | ||||||
| Core 2−/− | 11 | 62 | 35 ± 1 | 3600 ± 300 | 1200 ± 100 | 95 ± 6 |
| Control | 6 | 25 | 32 ± 1 | 4000 ± 400 | 1500 ± 150 | 100 ± 4 |
| TNF-treated | ||||||
| Core 2−/− | 11 | 55 | 37 ± 1 | 2900 ± 310 | 830 ± 100 | 81 ± 4 |
| Control | 11 | 43 | 37 ± 1 | 3500 ± 410 | 1020 ± 120 | 87 ± 7 |
| Mouse genotype . | Mice (n) . | Venules (n) . | Diameter (μm) . | Centerline velocity (μm/s) . | Wall shear rate (s−1) . | Systemic blood pressure (mmHg) . |
|---|---|---|---|---|---|---|
| Untreated | ||||||
| Core 2−/− | 11 | 62 | 35 ± 1 | 3600 ± 300 | 1200 ± 100 | 95 ± 6 |
| Control | 6 | 25 | 32 ± 1 | 4000 ± 400 | 1500 ± 150 | 100 ± 4 |
| TNF-treated | ||||||
| Core 2−/− | 11 | 55 | 37 ± 1 | 2900 ± 310 | 830 ± 100 | 81 ± 4 |
| Control | 11 | 43 | 37 ± 1 | 3500 ± 410 | 1020 ± 120 | 87 ± 7 |
Diameters, centerline velocity, wall shear rate, and systolic blood pressure are presented as mean ± SEM of all investigated venules.
TNF indicates tumor necrosis factor.