Comparison of matching criteria in patients homozygous for hemoglobin S with and without CD36 deficiency
| Matching criterion . | CD36−SS patients (n = 14) . | CD36+ SS patients (n = 31) . | P . |
|---|---|---|---|
| Sex ratio (males/females) | 3.66 (11/3) | 2.87 (23/8) | 1.0 |
| Age (mean ± SD) | 19.6 ± 10.4 | 21.0 ± 10.5 | .67 |
| Geographical origin | |||
| Central Africa | 12 (85.7%) | 27 (87.0%) | .62 |
| West Africa | 2 (14.2%) | 4 (12.9%) | |
| No. α-globin genes4-150 | |||
| 2 genes | 0 | 2 (7.4%) | |
| 3 genes | 6 (50.0%) | 15 (55.5%) | .67 |
| 4 genes | 6 (50.0%) | 10 (37.0%) | |
| β-globin gene haplotype4-151 | |||
| Bantu haplotype‡ | 8 (61.5%) | 22 (75.8%) | |
| Benin haplotype4-153 | 4 (30.7%) | 7 (24.1%) | .94 |
| Bantu/Benin | 1 (7.6%) | 0 |
| Matching criterion . | CD36−SS patients (n = 14) . | CD36+ SS patients (n = 31) . | P . |
|---|---|---|---|
| Sex ratio (males/females) | 3.66 (11/3) | 2.87 (23/8) | 1.0 |
| Age (mean ± SD) | 19.6 ± 10.4 | 21.0 ± 10.5 | .67 |
| Geographical origin | |||
| Central Africa | 12 (85.7%) | 27 (87.0%) | .62 |
| West Africa | 2 (14.2%) | 4 (12.9%) | |
| No. α-globin genes4-150 | |||
| 2 genes | 0 | 2 (7.4%) | |
| 3 genes | 6 (50.0%) | 15 (55.5%) | .67 |
| 4 genes | 6 (50.0%) | 10 (37.0%) | |
| β-globin gene haplotype4-151 | |||
| Bantu haplotype‡ | 8 (61.5%) | 22 (75.8%) | |
| Benin haplotype4-153 | 4 (30.7%) | 7 (24.1%) | .94 |
| Bantu/Benin | 1 (7.6%) | 0 |
SS indicates homozygous for hemoglobin S.
The number of α-globin genes was not known for 2 CD36− patients and 4 CD36+ SS patients.
The β-globin gene haplotype was not known for 1 CD36− patient and 2 CD36+ SS patients.
The SS patients exhibiting a Bantu haplotype were either homozygous Bantu/Bantu (n = 29) or heterozygous Bantu/Cameroon (n = 1).
The SS patients exhibiting a Benin haplotype were either homozygous Benin/Benin (n = 8) or heterozygous Benin/Cameroon (n = 3).