Tissue iron content of adultFth+/+ and Fth+/− mice that received (+Fe) or did not receive (−Fe) iron dextran injections
| Age, injection status . | Liver . | Spleen . | Heart . | |||
|---|---|---|---|---|---|---|
| +/+ Mice . | +/− Mice . | +/+ Mice . | +/− Mice . | +/+ Mice . | +/− Mice . | |
| 25 weeks (−Fe) | 40 ± 15 | 43 ± 28 | 355 ± 118 | 257 ± 100 | 37 ± 24 | 78 ± 26 |
| 45 weeks (−Fe) | 84 ± 32 | 70 ± 7 | 184 ± 71 | 197 ± 124 | 93 ± 3 | 75 ± 12 |
| 45 weeks (+Fe) | 2000 ± 190 | 1910 ± 113 | 282 ± 104 | 374 ± 106 | 144 ± 58 | 168 ± 168 |
| Age, injection status . | Liver . | Spleen . | Heart . | |||
|---|---|---|---|---|---|---|
| +/+ Mice . | +/− Mice . | +/+ Mice . | +/− Mice . | +/+ Mice . | +/− Mice . | |
| 25 weeks (−Fe) | 40 ± 15 | 43 ± 28 | 355 ± 118 | 257 ± 100 | 37 ± 24 | 78 ± 26 |
| 45 weeks (−Fe) | 84 ± 32 | 70 ± 7 | 184 ± 71 | 197 ± 124 | 93 ± 3 | 75 ± 12 |
| 45 weeks (+Fe) | 2000 ± 190 | 1910 ± 113 | 282 ± 104 | 374 ± 106 | 144 ± 58 | 168 ± 168 |
Results are the mean ± SD of tissue iron measurements, expressed in μg Fe per gram wet tissue. They were performed on 3 animals of 25 weeks or 45 weeks of age for each genotype, with no iron injection (−Fe). An additional series (+Fe) of three 45-week-old animals received 3 iron dextran injections (10 mg iron each) at 5-day intervals and were then killed for tissue iron determinations.