Cellular genes isolated by suppressive subtractive hybridization
| Gene encoding . | HTLV . | n . | GenBank no. . |
|---|---|---|---|
| Transcription factors | |||
| EGR2 (early growth response protein) | 1 | J04076 | |
| JunB (component of AP1-complex) | * | 1 | M29039 |
| ESE-1a (Ets-like transcription factor) | 2 | U73844 | |
| B94 (TNF-α–inducible response protein) | 4 | M92357 | |
| BBC1 (breast basic conserved protein 1) | 2 | X64707 | |
| DEC1 (bHLH motif containing protein) | 2 | AB004066 | |
| Surface receptors | |||
| IL-2 receptor α-chain | * | 6 | X01057 |
| Ferritin L-chain | 1 | M11147 | |
| Transferrin receptor (T9) | * | 1 | X01060 |
| T-cell receptor α-chain | 1 | M13052 | |
| Tumor necrosis factor receptor II | 1 | S63368 | |
| HLA-DR | * | 7 | V00523 |
| β2-microglobulin | * | 2 | V00567 |
| Cytokines | |||
| I-309 (CC chemokine) | 30 | M57502 | |
| IFN-γ | * | 1 | U10360 |
| IL-13 | 2 | L13029 | |
| ISG15 (IFN-induced 15-kd protein) | 2 | M13755 | |
| Signal transduction proteins | |||
| Plk-1 (serin/threonin protein kinase) | 1 | X73458 | |
| PI3 kinase (phosphatidylinositol 3-kinase) | 1 | Z46973 | |
| hVH-3 (tyrosine protein phosphatase) | 2 | U16996 | |
| PAC1 (tyrosine protein phosphatase) | 2 | U23853 | |
| Cyclin G1 (apoptosis regulator) | 1 | X77794 | |
| p21WAF1/CIP1(CDK-inhibitor) | * | 3 | U24170 |
| DDB2 (damage-specific DNA protein) | 2 | U18300 | |
| Ly-GDI (GDP-dissociation inhibitor) | 1 | L20688 | |
| Rab9 (GTPase) | 1 | Z97074 | |
| e3B1 (Eps8-binding protein) | 2 | AF006516 | |
| SGN2 (signalosome subunit 2) | 2 | AF084260 | |
| D123 (S-phase entry regulator) | 1 | D14878 | |
| Calcyclin (Ca2+ binding protein) | 1 | J02763 | |
| A20 (TNF-α inducible protein) | * | 1 | M59465 |
| Thymosin β-4 (immune response modulator) | * | 2 | M17733 |
| HIAP1 (human inhibitor of apoptosis 1) | 1 | U45878 | |
| HTLV-1 transcripts | 16 | ||
| EST | 100 | ||
| Unknown | 2 | ||
| Others | 138 |
| Gene encoding . | HTLV . | n . | GenBank no. . |
|---|---|---|---|
| Transcription factors | |||
| EGR2 (early growth response protein) | 1 | J04076 | |
| JunB (component of AP1-complex) | * | 1 | M29039 |
| ESE-1a (Ets-like transcription factor) | 2 | U73844 | |
| B94 (TNF-α–inducible response protein) | 4 | M92357 | |
| BBC1 (breast basic conserved protein 1) | 2 | X64707 | |
| DEC1 (bHLH motif containing protein) | 2 | AB004066 | |
| Surface receptors | |||
| IL-2 receptor α-chain | * | 6 | X01057 |
| Ferritin L-chain | 1 | M11147 | |
| Transferrin receptor (T9) | * | 1 | X01060 |
| T-cell receptor α-chain | 1 | M13052 | |
| Tumor necrosis factor receptor II | 1 | S63368 | |
| HLA-DR | * | 7 | V00523 |
| β2-microglobulin | * | 2 | V00567 |
| Cytokines | |||
| I-309 (CC chemokine) | 30 | M57502 | |
| IFN-γ | * | 1 | U10360 |
| IL-13 | 2 | L13029 | |
| ISG15 (IFN-induced 15-kd protein) | 2 | M13755 | |
| Signal transduction proteins | |||
| Plk-1 (serin/threonin protein kinase) | 1 | X73458 | |
| PI3 kinase (phosphatidylinositol 3-kinase) | 1 | Z46973 | |
| hVH-3 (tyrosine protein phosphatase) | 2 | U16996 | |
| PAC1 (tyrosine protein phosphatase) | 2 | U23853 | |
| Cyclin G1 (apoptosis regulator) | 1 | X77794 | |
| p21WAF1/CIP1(CDK-inhibitor) | * | 3 | U24170 |
| DDB2 (damage-specific DNA protein) | 2 | U18300 | |
| Ly-GDI (GDP-dissociation inhibitor) | 1 | L20688 | |
| Rab9 (GTPase) | 1 | Z97074 | |
| e3B1 (Eps8-binding protein) | 2 | AF006516 | |
| SGN2 (signalosome subunit 2) | 2 | AF084260 | |
| D123 (S-phase entry regulator) | 1 | D14878 | |
| Calcyclin (Ca2+ binding protein) | 1 | J02763 | |
| A20 (TNF-α inducible protein) | * | 1 | M59465 |
| Thymosin β-4 (immune response modulator) | * | 2 | M17733 |
| HIAP1 (human inhibitor of apoptosis 1) | 1 | U45878 | |
| HTLV-1 transcripts | 16 | ||
| EST | 100 | ||
| Unknown | 2 | ||
| Others | 138 |
HTLV indicates human T-cell leukemia virus type 1; n, number of complementary DNA isolations; TNF-α, tumor necrosis factor-α; IL-2, interleukin-2; IFN-γ, interferon γ; EST, expressed sequence tag.
Tax-/ATL-associated genes.