Table 1.

Patient characteristics

Patient characteristicsTCD BMT + DLI N = 24TCD BMT N = 38All patients N = 62P
Age (y)     
 <40 2  (8%) 8  (21%) 10  (16%) .29  
 ≥40 22  (92%) 30  (79%) 52  (84%)  
Donor-patient gender     
 Female-male 6  (25%) 13  (34%) 19  (31%) .57  
 Other 18  (75%) 25  (66%) 43  (69%)  
Stage at diagnosis     
 I-II 11  (46%) 15  (39%) 26  (42%) .79  
 III 13  (54%) 23  (61%) 36  (58%)  
Type of myeloma     
 IgA 4  (17%) 15  (11%) 8  (13%) .70  
 Other 20  (83%) 34  (89%) 54  (87%)  
Time from diagnosis to BMT     
 <1 year 13  (54%) 12  (32%) 25  (40%) .11  
 ≥1 year 11  (46%) 26  (68%) 37  (60%)  
No. of treatments prior to BMT     
 1 5  (21%) 3  (8%) 8  (13%) .24  
 ≥2 19  (79%) 35  (92%) 54  (87%)  
Conditioning regimens     
 CTX/TBI* 21  (88%) 35  (92%) 56  (92%)  
 CTX/BU 3  (12%) 3  (8%) 6  (9%)  
Patient characteristicsTCD BMT + DLI N = 24TCD BMT N = 38All patients N = 62P
Age (y)     
 <40 2  (8%) 8  (21%) 10  (16%) .29  
 ≥40 22  (92%) 30  (79%) 52  (84%)  
Donor-patient gender     
 Female-male 6  (25%) 13  (34%) 19  (31%) .57  
 Other 18  (75%) 25  (66%) 43  (69%)  
Stage at diagnosis     
 I-II 11  (46%) 15  (39%) 26  (42%) .79  
 III 13  (54%) 23  (61%) 36  (58%)  
Type of myeloma     
 IgA 4  (17%) 15  (11%) 8  (13%) .70  
 Other 20  (83%) 34  (89%) 54  (87%)  
Time from diagnosis to BMT     
 <1 year 13  (54%) 12  (32%) 25  (40%) .11  
 ≥1 year 11  (46%) 26  (68%) 37  (60%)  
No. of treatments prior to BMT     
 1 5  (21%) 3  (8%) 8  (13%) .24  
 ≥2 19  (79%) 35  (92%) 54  (87%)  
Conditioning regimens     
 CTX/TBI* 21  (88%) 35  (92%) 56  (92%)  
 CTX/BU 3  (12%) 3  (8%) 6  (9%)  

TCD indicates T-cell depleted; BMT, bone marrow transplantation; DLI, donor lymphocyte infusion; IgA, immunoglobulin A; TBI, total body irradiation; BU, busulfan.

*

Cyclophosphamide 60 mg/kg × 2, TBI 1400 cGy.

Cyclophosphamide 60 mg/kg × 2, busulfan 16 mg/kg.

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