TP53 status in CLL patients with p53 dysfunction
| Case . | Base change . | Predicted codon change . |
|---|---|---|
| 63-150 | None | None |
| 83-150 | None | None |
| 93-151 | 413 C→T (exon 5) | 138 A→V |
| 103-151 | 430 C→T (exon 5) | 144 Q→stop |
| 113-151 | 584 T→A (exon 6) | 195 I→N |
| 123-151 | 764 T→A (exon 7) | 255 I→N |
| 193-150 | None | None |
| 243-150 | None | None |
| 353-150 | None | None |
| 363-150 | None | None |
| 393-151 | 743 G→A (exon 7) | 248 R→Q |
| 403-150 | None | None |
| 423-151 | 673-681 del 9nt | del 225-227 V,G,S |
| Case . | Base change . | Predicted codon change . |
|---|---|---|
| 63-150 | None | None |
| 83-150 | None | None |
| 93-151 | 413 C→T (exon 5) | 138 A→V |
| 103-151 | 430 C→T (exon 5) | 144 Q→stop |
| 113-151 | 584 T→A (exon 6) | 195 I→N |
| 123-151 | 764 T→A (exon 7) | 255 I→N |
| 193-150 | None | None |
| 243-150 | None | None |
| 353-150 | None | None |
| 363-150 | None | None |
| 393-151 | 743 G→A (exon 7) | 248 R→Q |
| 403-150 | None | None |
| 423-151 | 673-681 del 9nt | del 225-227 V,G,S |
All 13 patients with type B
or A
p53 dysfunction were subjected to TP53 mutation analysis. The entire coding region was sequenced in both orientations from a combination of genomic PCR and RT-PCR products, as detailed in “Patients, materials, and methods.” Nucleotide positions relate to cDNA and are numbered from the ATG codon.