BV subfamilies showing abnormal CDR3 size pattern at different time points
| Patient no. . | GVHD (days of duration) . | BV number with abnormal CDR3 size pattern . | |||
|---|---|---|---|---|---|
| Day 12 . | Day 19 . | Day 26 . | Day 33 . | ||
| 2 | − | NT | NT | 1, 5S2, 8, 16 | |
| 3 | + (24-30) | NT | NT | 5S2, 15, 16 | NT |
| 6 | + (25-32) | NT | NT | 2, 4, 16 | NT |
| 8 | + (26-35) | NT | NT | 2, 4, 9, 12, 16, 20 | NT |
| 9 | + (23-26) | NT | NT | 18, 20, 23 | NT |
| 11 | − | − | NT | NT | 22 |
| 12 | − | 15 | NT | NT | 15, 16 |
| 13 | − | NT | NT | NT | − |
| 14 | + (23-27) | − | − | − | 16, 17 |
| 15 | + (25-29) | NT | 8, 24 | NT | 8, 22 |
| 16 | − | 8, 15 | 8 | NT | 8 |
| 17 | − | − | NT | − | NT |
| 18 | − | NT | 5S1, 22 | NT | 17, 22 |
| 19 | + (13-15) | − | 7 | − | − |
| 20 | + (26-29) | NT | 16, 22 | NT | 9, 16, 17, 22 |
| 21 | − | − | − | − | − |
| 22 | + (8-25) | NT | 5S2, 13S1, 16, 17 | NT | NT |
| 23 | − | − | 16 | 2, 16, 17 | 2, 13S2, 16 |
| 24 | − | NT | − | NT | 16 |
| 25 | + (18-34) | 15, 16 | 22 | 21 | 8, 17, 21, 22 |
| 26 | − | − | NT | NT | − |
| 27 | − | NT | 9, 20 | 9, 20 | NT |
| 28 | + (25-39) | NT | NT | 13S1, 16 | NT |
| 29 | − | 15, 16 | NT | NT | 5S1, 16, 24 |
| 30 | − | − | NT | NT | − |
| 31 | − | NT | 12, 14, 15, 24 | NT | NT |
| Patient no. . | GVHD (days of duration) . | BV number with abnormal CDR3 size pattern . | |||
|---|---|---|---|---|---|
| Day 12 . | Day 19 . | Day 26 . | Day 33 . | ||
| 2 | − | NT | NT | 1, 5S2, 8, 16 | |
| 3 | + (24-30) | NT | NT | 5S2, 15, 16 | NT |
| 6 | + (25-32) | NT | NT | 2, 4, 16 | NT |
| 8 | + (26-35) | NT | NT | 2, 4, 9, 12, 16, 20 | NT |
| 9 | + (23-26) | NT | NT | 18, 20, 23 | NT |
| 11 | − | − | NT | NT | 22 |
| 12 | − | 15 | NT | NT | 15, 16 |
| 13 | − | NT | NT | NT | − |
| 14 | + (23-27) | − | − | − | 16, 17 |
| 15 | + (25-29) | NT | 8, 24 | NT | 8, 22 |
| 16 | − | 8, 15 | 8 | NT | 8 |
| 17 | − | − | NT | − | NT |
| 18 | − | NT | 5S1, 22 | NT | 17, 22 |
| 19 | + (13-15) | − | 7 | − | − |
| 20 | + (26-29) | NT | 16, 22 | NT | 9, 16, 17, 22 |
| 21 | − | − | − | − | − |
| 22 | + (8-25) | NT | 5S2, 13S1, 16, 17 | NT | NT |
| 23 | − | − | 16 | 2, 16, 17 | 2, 13S2, 16 |
| 24 | − | NT | − | NT | 16 |
| 25 | + (18-34) | 15, 16 | 22 | 21 | 8, 17, 21, 22 |
| 26 | − | − | NT | NT | − |
| 27 | − | NT | 9, 20 | 9, 20 | NT |
| 28 | + (25-39) | NT | NT | 13S1, 16 | NT |
| 29 | − | 15, 16 | NT | NT | 5S1, 16, 24 |
| 30 | − | − | NT | NT | − |
| 31 | − | NT | 12, 14, 15, 24 | NT | NT |
BV indicates β-chain variable region; CDR3, complementarity-determining region 3; NT, not tested; +, GVHD developed; −, GVHD did not develop or abnormal pattern did not appear.