Table 3. Molecular cytogenetics of... | American Society of Hematology

Table 3.

Molecular cytogenetics of leukemic cells at diagnosis versus relapse

Patient	Status	TEL/AML FISH								Cytogenetics
		Interphase (%)					Metaphases
		Negative	Positive	+21	TEL deletion	+ider(21)^3-150	Negative	Positive	+ider(21)^3-150
1	Dgn	38	62	0	60	7	0	0	0	44,XX,-X,-9,-12,+mar [4] 46,XX [9]^3-151
	Rel	29	71	0	0	48	0	0	0	46,XX [8]
2	Dgn	20	80	20	65	0	8	3	0	46,XY [1]
	Rel	9	91	0	0	85	1	7	7	47,XY,t(5;14)(q13;q33),+21 [17] 46,XY [3]
3	Dgn	60	40	0	32	0	4	0	0	46,XY,del(12)(p13) [20]
	Rel	34	66	0	66	0	0	0	0	—

Patient	Status	TEL/AML FISH								Cytogenetics
		Interphase (%)					Metaphases
		Negative	Positive	+21	TEL deletion	+ider(21)^3-150	Negative	Positive	+ider(21)^3-150
1	Dgn	38	62	0	60	7	0	0	0	44,XX,-X,-9,-12,+mar [4] 46,XX [9]^3-151
	Rel	29	71	0	0	48	0	0	0	46,XX [8]
2	Dgn	20	80	20	65	0	8	3	0	46,XY [1]
	Rel	9	91	0	0	85	1	7	7	47,XY,t(5;14)(q13;q33),+21 [17] 46,XY [3]
3	Dgn	60	40	0	32	0	4	0	0	46,XY,del(12)(p13) [20]
	Rel	34	66	0	66	0	0	0	0	—

FISH indicates fluorescence in situ hybridization; dgn, diagnosis; rel, relapse.

F3-150

ider(21)(q10) t(12;21)(p13;q22).

F3-151

Note that subsequent interphase FISH analyses indicated that most leukemic cells retained both copies of chromosome 12 but had lost one copy of X and 9 (see “Results”).

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