Total bone marrow cellularity and absolute number of cell types from mice aged 8 to 10 weeks
| Genotype . | n . | Average cellularity/femur (107) . | mAb (Absolute cell no. 107) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PGP1 . | B220 . | Ly6G . | CD11b . | CD14 . | PMN . | Ter-119 . | |||
| Fancc+/+Sod1+/+ | 6 | 3.98 ± 0.62 | 2.89 | 0.86 | 1.28 | 1.33 | 0.05 | 1.21 | 1.36 |
| Fancc+/−Sod1+/− | 7 | 4.08 ± 0.57 | 3.14 | 1.21 | 1.48 | 1.42 | 0.14 | 1.46 | 1.30 |
| Fancc−/− | 6 | 3.41 ± 0.33 | 2.21 | 0.77 | 0.87 | 0.77 | 0.04 | 0.73 | 1.2 |
| Sod1−/− | 5 | 3.53 ± 0.57 | 2.7 | 0.88 | 1.23 | 1.2 | 0.06 | 1.1 | 1.05 |
| Fancc−/−Sod1−/− | 6 | 2.33 ± 0.19 | 1.68 | 0.56 | 0.79 | 0.73 | 0.01 | 0.85 | 0.72 |
| Genotype . | n . | Average cellularity/femur (107) . | mAb (Absolute cell no. 107) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PGP1 . | B220 . | Ly6G . | CD11b . | CD14 . | PMN . | Ter-119 . | |||
| Fancc+/+Sod1+/+ | 6 | 3.98 ± 0.62 | 2.89 | 0.86 | 1.28 | 1.33 | 0.05 | 1.21 | 1.36 |
| Fancc+/−Sod1+/− | 7 | 4.08 ± 0.57 | 3.14 | 1.21 | 1.48 | 1.42 | 0.14 | 1.46 | 1.30 |
| Fancc−/− | 6 | 3.41 ± 0.33 | 2.21 | 0.77 | 0.87 | 0.77 | 0.04 | 0.73 | 1.2 |
| Sod1−/− | 5 | 3.53 ± 0.57 | 2.7 | 0.88 | 1.23 | 1.2 | 0.06 | 1.1 | 1.05 |
| Fancc−/−Sod1−/− | 6 | 2.33 ± 0.19 | 1.68 | 0.56 | 0.79 | 0.73 | 0.01 | 0.85 | 0.72 |
Average BM cellularity/femur is represented as the average ± SEM. Fancc−/−Sod1−/−cellularity was decreased by approximately 52% compared withFancc+/−Sod1+/− (P= .08). Absolute numbers represent the average % staining × average cellularity and was consistantly reduced by a minimum of 40% compared with Fancc+/−Sod1+/−controls. Cellularity was decreased in Sod1−/−and Fancc−/− mice as well.