Genes whose expression is down-regulated in mantle cell lymphoma compared to hyperplastic lymph nodes as analyzed by oligonucleotide microarray
| Gene . | Access . | Map . | Description . | Change . |
|---|---|---|---|---|
| Apoptosis-related genes | ||||
| CASP9 | U60521 | Caspase 9, apoptosis-related cysteine protease | > 10 | |
| CASP10 | U60519 | 2q33-q34 | Caspase 10, apoptosis-related cysteine protease | 8 |
| CHARAS1 | J00277 | C-Ha-ras1 p21 proto-oncogene | > 10 | |
| RAIDD | U79115 | 12q21.33 | CASP2 and RIPK1 domain-containing adaptor with death domain | > 10 |
| CYC1 | J0444 | 8q24.3 | Cytochrome C1 | > 10 |
| FADD | X84709 | 11q13.3 | Fas (TNFRSF6)-associated via death domain | > 10 |
| DAXX | AF006041 | 6p21.3 | Death-associated protein 6 | 3 |
| PDCD1 | U64863 | 2q37.3 | Programmed cell death 1 | > 10 |
| RIN1 | L36463 | Ras interactor | 3 | |
| Retinoid acid–related genes | ||||
| RARA | X06614 | 17q12 | Retinoic acid receptor, alpha | 8 |
| RARG | M38258 | 12q13 | Retinoic acid receptor, gamma | > 10 |
| RI58 | U34605 | Retinoic acid and interferon–inducible 58K protein | > 10 | |
| RORA | U04898 | 15q21 | RAR-related orphan receptor A | > 10 |
| Kinases | ||||
| PRKAA2 | U06454 | 1p31 | Protein kinase, AMP-activated, alpha 2 | 3 |
| PRKG1 | Y07512 | 10q11.2 | Protein kinase, cGMP-dependent, type I | 8 |
| PRKM7 | U29725 | 17p11.2 | Protein kinase mitogen-activated 7 (MAP kinase) | > 10 |
| Growth factors/receptors | ||||
| IFI17 | J04164 | Interferon-induced protein 17 | 3 | |
| IFNAR1 | J03171 | 21q22.1 | Interferon (alpha, beta, and omega) receptor 1 | 10 |
| IL-1RL2 | U49065 | Interleukin-1 receptor-like 2 | 10 | |
| IL-6R | M20566 | 1q21 | Interleukin-6 receptor | 10 |
| IL-9R | L39064 | Xq28 | Interleukin-9 receptor | 4 |
| IL-11RA | U32324 | 9p13 | Interleukin-11 receptor, alpha | > 10 |
| IL-12RB2 | U64198 | 1p31.3 | Interleukin-12 receptor, beta 2 | 10 |
| IL-15RA | U31628 | 10p15 | Interleukin-15 receptor, alpha | > 10 |
| IL-18R1 | U43672 | 2q12 | Interleukin-18 receptor 1 | 3 |
| TGFBR3 | L07594 | 1p33-p32 | Transforming growth factor, beta receptor III | 8 |
| TNFRSF12 | U83598 | 1p36.2 | TNF receptor superfamily, member 12 | 4 |
| TNFRSF1A | M58286 | 12p13.2 | TNF receptor superfamily, member 1A | > 10 |
| Cell-cycle–related genes | ||||
| CCNA1 | U66838 | 13q12.3 | Cyclin A1 | 5 |
| CDC34 | L22005 | 19p13.3 | Cell division cycle 34 | > 10 |
| MAD1L1 | U33822 | 7p22 | MAD1 (mitotic arrest deficient, yeast, homolog) | 3 |
| MAD2L1 | U65410 | 4q27 | MAD2 (mitotic arrest deficient, yeast, homolog) | 4 |
| RBBP1 | S57153 | Retinoblastoma-binding protein 1 | 10 | |
| Others | ||||
| APR | D90070 | Adult T-cell leukemia–derived PMA-responsive | 3 | |
| H1F4 | M60748 | 6p22.2 | H1 histone family, member 4 | 6 |
| KIR2DL4 | X99479 | 19q13.4 | Killer cell immunoglobulin-like receptor | 10 |
| KLRC1 | X54867 | 12p13 | Killer cell lectin-like receptor subfamily C | > 10 |
| MAGEB1 | X82539 | Xp21.3 | Melanoma antigen, family B, 1 | > 10 |
| PPP2R5B | L42374 | 11q12 | Protein phosphatase 2, regulatory subunit B | > 10 |
| TAF2A | D90359 | Xq13.1 | TATA box binding protein associated factor | 10 |
| TAL1 | M63589 | 1p32 | T-cell acute lymphocytic leukemia 1 | 3 |
| XPA | D14533 | 9q22.3 | Xeroderma pigmentosum, complementation A | > 10 |
| Gene . | Access . | Map . | Description . | Change . |
|---|---|---|---|---|
| Apoptosis-related genes | ||||
| CASP9 | U60521 | Caspase 9, apoptosis-related cysteine protease | > 10 | |
| CASP10 | U60519 | 2q33-q34 | Caspase 10, apoptosis-related cysteine protease | 8 |
| CHARAS1 | J00277 | C-Ha-ras1 p21 proto-oncogene | > 10 | |
| RAIDD | U79115 | 12q21.33 | CASP2 and RIPK1 domain-containing adaptor with death domain | > 10 |
| CYC1 | J0444 | 8q24.3 | Cytochrome C1 | > 10 |
| FADD | X84709 | 11q13.3 | Fas (TNFRSF6)-associated via death domain | > 10 |
| DAXX | AF006041 | 6p21.3 | Death-associated protein 6 | 3 |
| PDCD1 | U64863 | 2q37.3 | Programmed cell death 1 | > 10 |
| RIN1 | L36463 | Ras interactor | 3 | |
| Retinoid acid–related genes | ||||
| RARA | X06614 | 17q12 | Retinoic acid receptor, alpha | 8 |
| RARG | M38258 | 12q13 | Retinoic acid receptor, gamma | > 10 |
| RI58 | U34605 | Retinoic acid and interferon–inducible 58K protein | > 10 | |
| RORA | U04898 | 15q21 | RAR-related orphan receptor A | > 10 |
| Kinases | ||||
| PRKAA2 | U06454 | 1p31 | Protein kinase, AMP-activated, alpha 2 | 3 |
| PRKG1 | Y07512 | 10q11.2 | Protein kinase, cGMP-dependent, type I | 8 |
| PRKM7 | U29725 | 17p11.2 | Protein kinase mitogen-activated 7 (MAP kinase) | > 10 |
| Growth factors/receptors | ||||
| IFI17 | J04164 | Interferon-induced protein 17 | 3 | |
| IFNAR1 | J03171 | 21q22.1 | Interferon (alpha, beta, and omega) receptor 1 | 10 |
| IL-1RL2 | U49065 | Interleukin-1 receptor-like 2 | 10 | |
| IL-6R | M20566 | 1q21 | Interleukin-6 receptor | 10 |
| IL-9R | L39064 | Xq28 | Interleukin-9 receptor | 4 |
| IL-11RA | U32324 | 9p13 | Interleukin-11 receptor, alpha | > 10 |
| IL-12RB2 | U64198 | 1p31.3 | Interleukin-12 receptor, beta 2 | 10 |
| IL-15RA | U31628 | 10p15 | Interleukin-15 receptor, alpha | > 10 |
| IL-18R1 | U43672 | 2q12 | Interleukin-18 receptor 1 | 3 |
| TGFBR3 | L07594 | 1p33-p32 | Transforming growth factor, beta receptor III | 8 |
| TNFRSF12 | U83598 | 1p36.2 | TNF receptor superfamily, member 12 | 4 |
| TNFRSF1A | M58286 | 12p13.2 | TNF receptor superfamily, member 1A | > 10 |
| Cell-cycle–related genes | ||||
| CCNA1 | U66838 | 13q12.3 | Cyclin A1 | 5 |
| CDC34 | L22005 | 19p13.3 | Cell division cycle 34 | > 10 |
| MAD1L1 | U33822 | 7p22 | MAD1 (mitotic arrest deficient, yeast, homolog) | 3 |
| MAD2L1 | U65410 | 4q27 | MAD2 (mitotic arrest deficient, yeast, homolog) | 4 |
| RBBP1 | S57153 | Retinoblastoma-binding protein 1 | 10 | |
| Others | ||||
| APR | D90070 | Adult T-cell leukemia–derived PMA-responsive | 3 | |
| H1F4 | M60748 | 6p22.2 | H1 histone family, member 4 | 6 |
| KIR2DL4 | X99479 | 19q13.4 | Killer cell immunoglobulin-like receptor | 10 |
| KLRC1 | X54867 | 12p13 | Killer cell lectin-like receptor subfamily C | > 10 |
| MAGEB1 | X82539 | Xp21.3 | Melanoma antigen, family B, 1 | > 10 |
| PPP2R5B | L42374 | 11q12 | Protein phosphatase 2, regulatory subunit B | > 10 |
| TAF2A | D90359 | Xq13.1 | TATA box binding protein associated factor | 10 |
| TAL1 | M63589 | 1p32 | T-cell acute lymphocytic leukemia 1 | 3 |
| XPA | D14533 | 9q22.3 | Xeroderma pigmentosum, complementation A | > 10 |
These genes were selected because their expression was down-regulated ≥ 3-fold in at least 4 of 5 mantle cell lymphoma samples as compared to the nonmalignant hyperplastic lymph nodes.
Access indicates GenBank accession number.