Table 3.

Toxicity and supportive care requirements of induction courses 1 and 2

Course 1Course 2
DATADEMACDATADEMAC
Hematologic toxicity, median days from end of course to       
 Neutrophils, more than 1.0 × 109/L 20 19 24 19 18 22  
 Platelets, more than 100 × 109/L 21 22 22 20 19 20 
Nonhematologic toxicity, mean World Health Organization grade       
 Nausea/vomiting 1.1 1.2 1.0 0.8 0.9 0.8 
 Alopecia 2.0 2.0 1.8 2.7 2.6 2.3  
 Oral toxicity 1.1 1.2 0.9 0.6 0.8 0.7 
 Diarrhea 1.0 1.2 0.6 0.5 0.6 0.4  
 Cardiac function 0.4 0.4 0.3 0.1 0.2 0.1  
Supportive care       
 Units of blood, mean 12 12 11 5 6 6  
 Units of platelets, mean 51 48 39 18 21 22  
 Days on IV antibiotics, mean 20 20 18 8 12 11  
 Days in hospital, median 28 27 25 20 21 22 
Course 1Course 2
DATADEMACDATADEMAC
Hematologic toxicity, median days from end of course to       
 Neutrophils, more than 1.0 × 109/L 20 19 24 19 18 22  
 Platelets, more than 100 × 109/L 21 22 22 20 19 20 
Nonhematologic toxicity, mean World Health Organization grade       
 Nausea/vomiting 1.1 1.2 1.0 0.8 0.9 0.8 
 Alopecia 2.0 2.0 1.8 2.7 2.6 2.3  
 Oral toxicity 1.1 1.2 0.9 0.6 0.8 0.7 
 Diarrhea 1.0 1.2 0.6 0.5 0.6 0.4  
 Cardiac function 0.4 0.4 0.3 0.1 0.2 0.1  
Supportive care       
 Units of blood, mean 12 12 11 5 6 6  
 Units of platelets, mean 51 48 39 18 21 22  
 Days on IV antibiotics, mean 20 20 18 8 12 11  
 Days in hospital, median 28 27 25 20 21 22 

For abbreviations, see Table 1.

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