Clinical and demographic characteristics of 854 AML patients
| . | Total . | FLT3/ITD− (percent total ITD−) . | FLT3/ITD+ (percent total ITD+) . | Percent FLT3/ITD+ . | P . |
|---|---|---|---|---|---|
| Total | 854 | 627 | 227 | 27% | |
| AML 10 | 406 (48%) | 301 (48%) | 105 (46%) | 26% | .7 |
| AML 12 | 448 (52%) | 326 (52%) | 122 (54%) | 27% | |
| De novo | 792 (93%) | 582 (93%) | 210 (93%) | 27% | .9 |
| Secondary | 62 (7%) | 45 (7%) | 17 (7%) | 27% | |
| FAB type | |||||
| M0 | 14 (2%) | 14 (2%) | 0 (0%) | 0% | .02 |
| M1 | 148 (17%) | 108 (17%) | 40 (18%) | 27% | 1.0 |
| M2 | 210 (25%) | 161 (26%) | 49 (22%) | 23% | .2 |
| M3 | 159 (19%) | 101 (16%) | 58 (26%) | 36% | .004 |
| M4 | 172 (20%) | 121 (19%) | 51 (22%) | 29% | .4 |
| M5 | 81 (10%) | 61 (10%) | 20 (9%) | 25% | .7 |
| M6 | 15 (2%) | 14 (2%) | 1 (< 1%) | 7% | .08 |
| M7 | 11 (1%) | 11 (2%) | 0 (0%) | 0% | .04 |
| Bilineage | 1 (< 1%) | 0 (0%) | 1 (< 1%) | .3 | |
| RAEB-t | 8 (1%) | 7 (1%) | 1 (< 1%) | .7 | |
| Unknown | 35 (4%) | 29 (5%) | 6 (3%) | ||
| Sex | |||||
| Male | 432 (51%) | 322 (51%) | 110 (48%) | 25% | .5 |
| Female | 422 (49%) | 305 (49%) | 117 (52%) | 28% | |
| Age (y) | |||||
| Younger than 15 | 5 (1%) | 3 (< 1%) | 2 (1%) | 40% | .3 |
| 15-34 | 290 (34%) | 222 (35%) | 68 (30%) | 23% | |
| 35-54 | 477 (56%) | 342 (55%) | 135 (59%) | 28% | |
| 55 or older | 82 (10%) | 60 (10%) | 22 (10%) | 27% | |
| Median | 41 | 41 | 42 | .2 | |
| WBC count (× 109/L) | |||||
| Below 10 | 300 (35%) | 251 (40%) | 49 (22%) | 16% | < .001 |
| 10-19 | 132 (16%) | 98 (16%) | 34 (15%) | 26% | |
| 20-49 | 168 (20%) | 125 (20%) | 43 (19%) | 26% | |
| 50-99 | 120 (14%) | 76 (12%) | 44 (19%) | 37% | |
| 100 or above | 116 (14%) | 63 (10%) | 53 (23%) | 46% | |
| Median | 18.3 | 14.3 | 38 | < .001 | |
| Percent BM blasts | |||||
| Below 80% | 349 (41%) | 285 (45%) | 64 (28%) | 18% | < .001 |
| 80% or above | 417 (49%) | 278 (44%) | 139 (61%) | 33% | |
| Median | 80 | 79 | 87 | < .001 |
| . | Total . | FLT3/ITD− (percent total ITD−) . | FLT3/ITD+ (percent total ITD+) . | Percent FLT3/ITD+ . | P . |
|---|---|---|---|---|---|
| Total | 854 | 627 | 227 | 27% | |
| AML 10 | 406 (48%) | 301 (48%) | 105 (46%) | 26% | .7 |
| AML 12 | 448 (52%) | 326 (52%) | 122 (54%) | 27% | |
| De novo | 792 (93%) | 582 (93%) | 210 (93%) | 27% | .9 |
| Secondary | 62 (7%) | 45 (7%) | 17 (7%) | 27% | |
| FAB type | |||||
| M0 | 14 (2%) | 14 (2%) | 0 (0%) | 0% | .02 |
| M1 | 148 (17%) | 108 (17%) | 40 (18%) | 27% | 1.0 |
| M2 | 210 (25%) | 161 (26%) | 49 (22%) | 23% | .2 |
| M3 | 159 (19%) | 101 (16%) | 58 (26%) | 36% | .004 |
| M4 | 172 (20%) | 121 (19%) | 51 (22%) | 29% | .4 |
| M5 | 81 (10%) | 61 (10%) | 20 (9%) | 25% | .7 |
| M6 | 15 (2%) | 14 (2%) | 1 (< 1%) | 7% | .08 |
| M7 | 11 (1%) | 11 (2%) | 0 (0%) | 0% | .04 |
| Bilineage | 1 (< 1%) | 0 (0%) | 1 (< 1%) | .3 | |
| RAEB-t | 8 (1%) | 7 (1%) | 1 (< 1%) | .7 | |
| Unknown | 35 (4%) | 29 (5%) | 6 (3%) | ||
| Sex | |||||
| Male | 432 (51%) | 322 (51%) | 110 (48%) | 25% | .5 |
| Female | 422 (49%) | 305 (49%) | 117 (52%) | 28% | |
| Age (y) | |||||
| Younger than 15 | 5 (1%) | 3 (< 1%) | 2 (1%) | 40% | .3 |
| 15-34 | 290 (34%) | 222 (35%) | 68 (30%) | 23% | |
| 35-54 | 477 (56%) | 342 (55%) | 135 (59%) | 28% | |
| 55 or older | 82 (10%) | 60 (10%) | 22 (10%) | 27% | |
| Median | 41 | 41 | 42 | .2 | |
| WBC count (× 109/L) | |||||
| Below 10 | 300 (35%) | 251 (40%) | 49 (22%) | 16% | < .001 |
| 10-19 | 132 (16%) | 98 (16%) | 34 (15%) | 26% | |
| 20-49 | 168 (20%) | 125 (20%) | 43 (19%) | 26% | |
| 50-99 | 120 (14%) | 76 (12%) | 44 (19%) | 37% | |
| 100 or above | 116 (14%) | 63 (10%) | 53 (23%) | 46% | |
| Median | 18.3 | 14.3 | 38 | < .001 | |
| Percent BM blasts | |||||
| Below 80% | 349 (41%) | 285 (45%) | 64 (28%) | 18% | < .001 |
| 80% or above | 417 (49%) | 278 (44%) | 139 (61%) | 33% | |
| Median | 80 | 79 | 87 | < .001 |
P values are for the Mantel-Haenszel test for trend in age, WBC count, percent BM blasts, and Fisher exact test for AML 10 versus AML 12, de novo versus secondary AML and each individual FAB type versus all other known FAB types.
RAEB-t indicates refractory anemia with excess blasts in transformation.