Clinical and demographic characteristics of patients grouped according to the number of FLT3/ITDs and the relative level of mutation
| . | One FLT3/ITD (percent of total with one FLT3/ITD) . | More than one FLT3/ITD (percent of total with more than one) . | P . | Less than 60% FLT3/ITD (percent of total with < 60%) . | 60% or more FLT3/ITD (percent of total with ≥ 60%) . | P . |
|---|---|---|---|---|---|---|
| Total | 173 | 51 | 201 | 23 | ||
| FAB type | ||||||
| M1 | 31 (18) | 8 (16) | .8 | 33 (16) | 6 (26) | .3 |
| M2 | 35 (20) | 14 (27) | .2 | 44 (22) | 5 (22) | 1.0 |
| M3 | 45 (26) | 12 (24) | .9 | 57 (28) | 0 (0) | .0008 |
| M4 | 39 (23) | 11 (22) | 1.0 | 40 (20) | 10 (43) | .02 |
| M5 | 17 (10) | 3 (6) | .6 | 18 (9) | 2 (9) | 1.0 |
| M6 | 1 (1) | 0 (0) | 1.0 | 1 (1) | 0 (0) | 1.0 |
| Cytogenetic risk group | ||||||
| Favorable | 44 (25) | 12 (24) | .3 | 56 (28) | 0 (0) | .03 |
| Intermediate | 105 (61) | 27 (53) | 116 (58) | 16 (70) | ||
| Adverse | 2 (1) | 4 (8) | 6 (3) | 0 (0) | ||
| Unknown | 22 (13) | 8 (16) | 23 (11) | 7 (30) | ||
| Age at entry | ||||||
| Younger than 15 | 1 (1) | 1 (2) | .8 | 2 (1) | 0 (0) | .5 |
| 15-34 | 50 (29) | 15 (29) | 61 (30) | 4 (17) | ||
| 35-54 | 105 (61) | 30 (59) | 117 (58) | 18 (78) | ||
| 55 or older | 17 (10) | 5 (10) | 21 (10) | 1 (4) | ||
| Median | 43 | 41 | .3 | 42 | 49 | .04 |
| WBC count (× 109/L) | ||||||
| Below 10 | 40 (23) | 7 (14) | .1 | 46 (23) | 1 (4) | .3 |
| 10-19 | 29 (17) | 5 (10) | 31 (15) | 3 (13) | ||
| 20-49 | 32 (19) | 10 (20) | 38 (19) | 4 (17) | ||
| 50-99 | 32 (19) | 12 (24) | 34 (17) | 10 (43) | ||
| 100 or above | 39 (23) | 14 (27) | 48 (24) | 5 (22) | ||
| Median | 34.4 | 51.5 | .07 | 35.2 | 63.0 | .03 |
| Percent BM blasts | ||||||
| Below 80% | 54 (31) | 10 (20) | .2 | 56 (28) | 8 (35) | .6 |
| 80% or above | 104 (60) | 33 (65) | 123 (61) | 14 (61) | ||
| Median | 86 | 90 | .07 | 86 | 87.5 | .5 |
| Sex | ||||||
| Male | 80 (46) | 28 (55) | .3 | 102 (51) | 6 (26) | .3 |
| Female | 93 (54) | 23 (45) | 99 (49) | 17 (74) |
| . | One FLT3/ITD (percent of total with one FLT3/ITD) . | More than one FLT3/ITD (percent of total with more than one) . | P . | Less than 60% FLT3/ITD (percent of total with < 60%) . | 60% or more FLT3/ITD (percent of total with ≥ 60%) . | P . |
|---|---|---|---|---|---|---|
| Total | 173 | 51 | 201 | 23 | ||
| FAB type | ||||||
| M1 | 31 (18) | 8 (16) | .8 | 33 (16) | 6 (26) | .3 |
| M2 | 35 (20) | 14 (27) | .2 | 44 (22) | 5 (22) | 1.0 |
| M3 | 45 (26) | 12 (24) | .9 | 57 (28) | 0 (0) | .0008 |
| M4 | 39 (23) | 11 (22) | 1.0 | 40 (20) | 10 (43) | .02 |
| M5 | 17 (10) | 3 (6) | .6 | 18 (9) | 2 (9) | 1.0 |
| M6 | 1 (1) | 0 (0) | 1.0 | 1 (1) | 0 (0) | 1.0 |
| Cytogenetic risk group | ||||||
| Favorable | 44 (25) | 12 (24) | .3 | 56 (28) | 0 (0) | .03 |
| Intermediate | 105 (61) | 27 (53) | 116 (58) | 16 (70) | ||
| Adverse | 2 (1) | 4 (8) | 6 (3) | 0 (0) | ||
| Unknown | 22 (13) | 8 (16) | 23 (11) | 7 (30) | ||
| Age at entry | ||||||
| Younger than 15 | 1 (1) | 1 (2) | .8 | 2 (1) | 0 (0) | .5 |
| 15-34 | 50 (29) | 15 (29) | 61 (30) | 4 (17) | ||
| 35-54 | 105 (61) | 30 (59) | 117 (58) | 18 (78) | ||
| 55 or older | 17 (10) | 5 (10) | 21 (10) | 1 (4) | ||
| Median | 43 | 41 | .3 | 42 | 49 | .04 |
| WBC count (× 109/L) | ||||||
| Below 10 | 40 (23) | 7 (14) | .1 | 46 (23) | 1 (4) | .3 |
| 10-19 | 29 (17) | 5 (10) | 31 (15) | 3 (13) | ||
| 20-49 | 32 (19) | 10 (20) | 38 (19) | 4 (17) | ||
| 50-99 | 32 (19) | 12 (24) | 34 (17) | 10 (43) | ||
| 100 or above | 39 (23) | 14 (27) | 48 (24) | 5 (22) | ||
| Median | 34.4 | 51.5 | .07 | 35.2 | 63.0 | .03 |
| Percent BM blasts | ||||||
| Below 80% | 54 (31) | 10 (20) | .2 | 56 (28) | 8 (35) | .6 |
| 80% or above | 104 (60) | 33 (65) | 123 (61) | 14 (61) | ||
| Median | 86 | 90 | .07 | 86 | 87.5 | .5 |
| Sex | ||||||
| Male | 80 (46) | 28 (55) | .3 | 102 (51) | 6 (26) | .3 |
| Female | 93 (54) | 23 (45) | 99 (49) | 17 (74) |
P values are Mantel-Haenszel test for the trend in cytogenetic risk, age, WBC count, percent BM blasts, and Fisher exact test for each individual FAB type versus all other known FAB types.