Table 2. Surface phenotype, T-cell... | American Society of Hematology

Table 2.

Surface phenotype, T-cell proliferative responses to various β₂GPI preparations, predicted β₂GPI domain containing the epitope, and HLA class II restriction in 14 β₂GPI-specific CD4⁺ T-cell clones

T-cell clones	Surface phenotype	Antigen-induced T-cell proliferative response					Predicted β₂GPI domain containing epitope	HLA class II restriction^*
T-cell clones	Surface phenotype	Native β₂GPI	Reduced β₂GPI	GP1	GP2	GP3	Predicted β₂GPI domain containing epitope	HLA class II restriction^*
Patient O.M.
OM2	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
OM3	CD4⁺CD8⁻	−	+	+	−	−	I/II	HLA-DP
OM7	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
OM8	CD4⁺CD8⁻	−	−	−	−	+	V	HLA-DR
Patient E.Y.
EY3	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
EY8	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
EY9	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
EY12	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
Patient K.S.
KS3	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS4	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS5	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS7	CD4⁺CD8⁻	−	+	−	+	+	IV	HLA-DR
KS8	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS10	CD4⁺CD8⁻	−	+	−	+	+	IV	HLA-DR

T-cell clones	Surface phenotype	Antigen-induced T-cell proliferative response					Predicted β₂GPI domain containing epitope	HLA class II restriction^*
T-cell clones	Surface phenotype	Native β₂GPI	Reduced β₂GPI	GP1	GP2	GP3	Predicted β₂GPI domain containing epitope	HLA class II restriction^*
Patient O.M.
OM2	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
OM3	CD4⁺CD8⁻	−	+	+	−	−	I/II	HLA-DP
OM7	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
OM8	CD4⁺CD8⁻	−	−	−	−	+	V	HLA-DR
Patient E.Y.
EY3	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
EY8	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
EY9	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
EY12	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
Patient K.S.
KS3	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS4	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS5	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS7	CD4⁺CD8⁻	−	+	−	+	+	IV	HLA-DR
KS8	CD4⁺CD8⁻	−	+	−	−	+	V	HLA-DR
KS10	CD4⁺CD8⁻	−	+	−	+	+	IV	HLA-DR

Determined based on blocking experiments using anti-HLA-DR, anti-HLA-DQ, and anti-HLA-DP mAbs.

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