Logistic regression model for primary neutrophil engraftment in evaluable patients surviving at least 21 days (n = 6518)
| Factor . | Primary neutrophil engraftment . | |||
|---|---|---|---|---|
| Odds ratio . | 95% CI . | P . | Favorable . | |
| Donor age (per decade) | 1.04 | 0.92-1.18 | .53 | NS |
| Donor CMV positive (CMV-negative recipient)3-150 | 0.75 | 0.56-1.02 | .07 | NS |
| Donor CMV positive (CMV-positive recipient)3-151 | 0.98 | 0.72-1.34 | .91 | NS |
| Male donor | 1.00 | — | — | — |
| Female donor (no pregnancies) | 0.86 | 0.65-1.14 | .30 | NS |
| Female donor (1 pregnancy) | 1.09 | 0.69-1.74 | .70 | NS |
| Female donor (≥2 pregnancies) | 0.99 | 0.75-1.31 | .95 | NS |
| ABO match | 1.00 | — | — | — |
| ABO minor mismatch | 1.12 | 0.86-1.48 | .40 | NS |
| ABO major mismatch | 0.95 | 0.74-1.21 | .68 | NS |
| Donor race mismatch (white recipient) | 0.90 | 0.67-1.20 | .47 | NS |
| Donor race mismatch (minority recipient) | 1.03 | 0.59-1.77 | .93 | NS |
| HLA-A, -B, DRB1 match3-152 | 1.00 | — | — | Matched |
| HLA-A mismatch3-150 | 0.58 | 0.42-0.80 | .0008 | — |
| HLA-B mismatch | 0.52 | 0.37-0.73 | .0002 | — |
| HLA-DRB1 mismatch | 0.52 | 0.38-0.72 | <.0001 | — |
| Factor . | Primary neutrophil engraftment . | |||
|---|---|---|---|---|
| Odds ratio . | 95% CI . | P . | Favorable . | |
| Donor age (per decade) | 1.04 | 0.92-1.18 | .53 | NS |
| Donor CMV positive (CMV-negative recipient)3-150 | 0.75 | 0.56-1.02 | .07 | NS |
| Donor CMV positive (CMV-positive recipient)3-151 | 0.98 | 0.72-1.34 | .91 | NS |
| Male donor | 1.00 | — | — | — |
| Female donor (no pregnancies) | 0.86 | 0.65-1.14 | .30 | NS |
| Female donor (1 pregnancy) | 1.09 | 0.69-1.74 | .70 | NS |
| Female donor (≥2 pregnancies) | 0.99 | 0.75-1.31 | .95 | NS |
| ABO match | 1.00 | — | — | — |
| ABO minor mismatch | 1.12 | 0.86-1.48 | .40 | NS |
| ABO major mismatch | 0.95 | 0.74-1.21 | .68 | NS |
| Donor race mismatch (white recipient) | 0.90 | 0.67-1.20 | .47 | NS |
| Donor race mismatch (minority recipient) | 1.03 | 0.59-1.77 | .93 | NS |
| HLA-A, -B, DRB1 match3-152 | 1.00 | — | — | Matched |
| HLA-A mismatch3-150 | 0.58 | 0.42-0.80 | .0008 | — |
| HLA-B mismatch | 0.52 | 0.37-0.73 | .0002 | — |
| HLA-DRB1 mismatch | 0.52 | 0.38-0.72 | <.0001 | — |
The model also adjusted for disease, transplant center, cell dose, T-cell depletion, recipient CMV status, and race (results not shown). An odds ratio greater than 1.00 indicates a favorable outcome for engraftment.
CI indicates confidence interval; CMV, cytomegalovirus; and NS, not significant.
Comparing CMV-seropositive donor with seronegative donor among seronegative recipients.
Comparing CMV-seropositive donor with seronegative donor among seropositive recipients.
Includes potential matches.