Proportional hazards regression models for grade III or IV acute graft-versus-host disease (GVHD) (n = 6978) and chronic GVHD (n = 4819 evaluable patients surviving at least 80 days)
| Factor . | Grade III-IV acute GVHD . | Chronic GVHD . | ||||||
|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | Favorable factor . | RR . | 95% CI . | P . | Favorable factor . | |
| Donor age (per decade) | 1.08 | 1.03-1.14 | .002 | Younger | 1.08 | 1.02-1.14 | .005 | Younger |
| Donor CMV positive (CMV-negative recipient)4-150 | 0.99 | 0.88-1.12 | .90 | NS | 1.02 | 0.90-1.15 | .77 | NS |
| Donor CMV positive (CMV-positive recipient)4-151 | 0.99 | 0.87-1.11 | .81 | NS | 0.95 | 0.83-1.09 | .46 | NS |
| Male donor | 1.00 | — | — | — | 1.00 | — | — | Male |
| Female donor (no pregnancies) | 1.04 | 0.92-1.17 | .53 | NS | 1.09 | 0.96-1.24 | .17 | Never |
| Female donor (1 pregnancy) | 0.94 | 0.78-1.12 | .48 | NS | 1.19 | 1.00-1.43 | .05 | Pregnant |
| Female donor (≥2 pregnancies) | 1.04 | 0.93-1.16 | .46 | NS | 1.40 | 1.25-1.57 | <.0001 | — |
| ABO match | 1.00 | — | — | — | 1.00 | — | — | — |
| ABO minor mismatch | 1.11 | 1.00-1.23 | .05 | NS | 1.01 | 0.90-1.12 | .92 | NS |
| ABO major mismatch | 1.02 | 0.93-1.13 | .67 | NS | 0.97 | 0.88-1.08 | .58 | NS |
| Donor race mismatch (white recipient) | 1.06 | 0.94-1.19 | .38 | NS | 0.98 | 0.86-1.12 | .74 | NS |
| Donor race mismatch (minority recipient) | 1.17 | 0.94-1.46 | .16 | NS | 1.16 | 0.90-1.51 | .25 | NS |
| HLA-A, -B, DRB1 match‡ | 1.00 | — | — | Matched | N/A | N/A | N/A | NS |
| HLA-A mismatch | 1.22 | 1.06-1.41 | .006 | — | N/A | N/A | N/A | NS |
| HLA-B mismatch | 1.47 | 1.26-1.71 | <.0001 | — | N/A | N/A | N/A | NS |
| HLA-DRB1 mismatch | 1.46 | 1.27-1.67 | <.0001 | — | N/A | N/A | N/A | NS |
| Factor . | Grade III-IV acute GVHD . | Chronic GVHD . | ||||||
|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | Favorable factor . | RR . | 95% CI . | P . | Favorable factor . | |
| Donor age (per decade) | 1.08 | 1.03-1.14 | .002 | Younger | 1.08 | 1.02-1.14 | .005 | Younger |
| Donor CMV positive (CMV-negative recipient)4-150 | 0.99 | 0.88-1.12 | .90 | NS | 1.02 | 0.90-1.15 | .77 | NS |
| Donor CMV positive (CMV-positive recipient)4-151 | 0.99 | 0.87-1.11 | .81 | NS | 0.95 | 0.83-1.09 | .46 | NS |
| Male donor | 1.00 | — | — | — | 1.00 | — | — | Male |
| Female donor (no pregnancies) | 1.04 | 0.92-1.17 | .53 | NS | 1.09 | 0.96-1.24 | .17 | Never |
| Female donor (1 pregnancy) | 0.94 | 0.78-1.12 | .48 | NS | 1.19 | 1.00-1.43 | .05 | Pregnant |
| Female donor (≥2 pregnancies) | 1.04 | 0.93-1.16 | .46 | NS | 1.40 | 1.25-1.57 | <.0001 | — |
| ABO match | 1.00 | — | — | — | 1.00 | — | — | — |
| ABO minor mismatch | 1.11 | 1.00-1.23 | .05 | NS | 1.01 | 0.90-1.12 | .92 | NS |
| ABO major mismatch | 1.02 | 0.93-1.13 | .67 | NS | 0.97 | 0.88-1.08 | .58 | NS |
| Donor race mismatch (white recipient) | 1.06 | 0.94-1.19 | .38 | NS | 0.98 | 0.86-1.12 | .74 | NS |
| Donor race mismatch (minority recipient) | 1.17 | 0.94-1.46 | .16 | NS | 1.16 | 0.90-1.51 | .25 | NS |
| HLA-A, -B, DRB1 match‡ | 1.00 | — | — | Matched | N/A | N/A | N/A | NS |
| HLA-A mismatch | 1.22 | 1.06-1.41 | .006 | — | N/A | N/A | N/A | NS |
| HLA-B mismatch | 1.47 | 1.26-1.71 | <.0001 | — | N/A | N/A | N/A | NS |
| HLA-DRB1 mismatch | 1.46 | 1.27-1.67 | <.0001 | — | N/A | N/A | N/A | NS |
These models also adjusted for disease, transplant center, T-cell depletion, year of infusion, and recipient age and race (results not shown).
RR indicates relative risk; CI, confidence interval; CMV, cytomegalovirus; NS, not significant; and N/A, not applicable (ie, factors excluded from the model because they were not statistically significant).
Comparing CMV-seropositive donor with seronegative donor among seronegative recipients.
Comparing CMV-seropositive donor with seronegative donor among seropositive recipients.
Includes potential matches.