Proportional hazards regression models for overall survival (n = 6978) and disease-free survival (n = 6230).
| Factor . | Overall Survival . | Disease-free Survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | Favorable . | RR . | 95% CI . | P . | Favorable . | |
| Donor age (per decade) | 1.10 | (1.06, 1.14) | < 0.0001 | Younger | 1.09 | (1.05, 1.13) | < 0.0001 | Younger |
| Donor CMV positive (CMV negative recipient)5-150 | 0.95 | (0.87, 1.04) | 0.28 | NS | 0.94 | (0.85, 1.03) | 0.17 | NS |
| Donor CMV positive (CMV positive recipient)5-151 | 1.03 | (0.95, 1.12) | 0.51 | NS | 1.03 | (0.94, 1.12) | 0.58 | NS |
| Male donor | 1.00 | 1.00 | ||||||
| Female donor—no pregnancies | 1.04 | (0.95, 1.13) | 0.43 | NS | 1.03 | (0.95, 1.13) | 0.50 | NS |
| Female donor—1 pregnancy | 0.91 | (0.80, 1.03) | 0.14 | NS | 0.92 | (0.80, 1.05) | 0.19 | NS |
| Female donor—2+ pregnancies | 0.99 | (0.92, 1.08) | 0.85 | NS | 1.00 | (0.92, 1.09) | 0.97 | NS |
| ABO match | 1.00 | 1.00 | ||||||
| ABO minor mismatch | 0.98 | (0.91, 1.05) | 0.54 | NS | 1.01 | (0.94, 1.09) | 0.76 | NS |
| ABO major mismatch | 1.01 | (0.94, 1.09) | 0.70 | NS | 1.01 | (0.94, 1.09) | 0.80 | NS |
| Donor race match (white recipient) | 1.05 | (0.96, 1.15) | 0.26 | NS | 1.05 | (0.96, 1.15) | 0.27 | NS |
| Donor race match (minority recipient) | 1.11 | (0.94, 1.31) | 0.23 | NS | 1.05 | (0.88, 1.25) | 0.56 | NS |
| HLA-A,B,DRB1 match5-152 | 1.00 | Matched | 1.00 | Matched | ||||
| HLA-A mismatch | 1.40 | (1.26, 1.54) | < 0.0001 | 1.38 | (1.24, 1.53) | < 0.0001 | ||
| HLA-B mismatch | 1.46 | (1.31, 1.64) | < 0.0001 | 1.43 | (1.27, 1.61) | < 0.0001 | ||
| HLA-DRB1 mismatch | 1.25 | (1.13, 1.38) | < 0.0001 | 1.20 | (1.08, 1.33) | 0.0007 | ||
| Factor . | Overall Survival . | Disease-free Survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | Favorable . | RR . | 95% CI . | P . | Favorable . | |
| Donor age (per decade) | 1.10 | (1.06, 1.14) | < 0.0001 | Younger | 1.09 | (1.05, 1.13) | < 0.0001 | Younger |
| Donor CMV positive (CMV negative recipient)5-150 | 0.95 | (0.87, 1.04) | 0.28 | NS | 0.94 | (0.85, 1.03) | 0.17 | NS |
| Donor CMV positive (CMV positive recipient)5-151 | 1.03 | (0.95, 1.12) | 0.51 | NS | 1.03 | (0.94, 1.12) | 0.58 | NS |
| Male donor | 1.00 | 1.00 | ||||||
| Female donor—no pregnancies | 1.04 | (0.95, 1.13) | 0.43 | NS | 1.03 | (0.95, 1.13) | 0.50 | NS |
| Female donor—1 pregnancy | 0.91 | (0.80, 1.03) | 0.14 | NS | 0.92 | (0.80, 1.05) | 0.19 | NS |
| Female donor—2+ pregnancies | 0.99 | (0.92, 1.08) | 0.85 | NS | 1.00 | (0.92, 1.09) | 0.97 | NS |
| ABO match | 1.00 | 1.00 | ||||||
| ABO minor mismatch | 0.98 | (0.91, 1.05) | 0.54 | NS | 1.01 | (0.94, 1.09) | 0.76 | NS |
| ABO major mismatch | 1.01 | (0.94, 1.09) | 0.70 | NS | 1.01 | (0.94, 1.09) | 0.80 | NS |
| Donor race match (white recipient) | 1.05 | (0.96, 1.15) | 0.26 | NS | 1.05 | (0.96, 1.15) | 0.27 | NS |
| Donor race match (minority recipient) | 1.11 | (0.94, 1.31) | 0.23 | NS | 1.05 | (0.88, 1.25) | 0.56 | NS |
| HLA-A,B,DRB1 match5-152 | 1.00 | Matched | 1.00 | Matched | ||||
| HLA-A mismatch | 1.40 | (1.26, 1.54) | < 0.0001 | 1.38 | (1.24, 1.53) | < 0.0001 | ||
| HLA-B mismatch | 1.46 | (1.31, 1.64) | < 0.0001 | 1.43 | (1.27, 1.61) | < 0.0001 | ||
| HLA-DRB1 mismatch | 1.25 | (1.13, 1.38) | < 0.0001 | 1.20 | (1.08, 1.33) | 0.0007 | ||
Analysis of disease-free survival was restricted to malignant diseases. These models also adjusted for disease, transplant center, T-cell depletion, cell dose, interval from diagnosis to transplant (chronic phase CML and SAA) recipient age, sex (overall survival only) and race (results not shown). NS indicates not significant.
Comparing CMV-seropositive donor vs seronegative donor among seronegative recipients.
Comparing CMV-seropositive donor vs seronegative donor among seropositive recipients.
Includes potential matches.