Table 2. Lymphocyte subsets in ALPS Ia... | American Society of Hematology

Table 2.

Lymphocyte subsets in ALPS Ia families, probands with ALPS II/III, and HCs

Lymphocyte subset	Proband Ia (n = 31)		M⁺/A⁺ (n = 28)		M⁺/A^⁻ (n = 42)		M⁻/A⁻ (n = 65)		Proband II/III (n = 11)		HC (n = 40)
T cells
CD3⁺	*2239^↑**	[70.9^†]	1768↑	[74.1]	1159	[76.7]	1487↑	[76.1]	2138↑	[71.5]	1105	[72.2]
CD4⁺	824	[27.5]	712	[34.3]	654	[43.2]	841	[44.6]	800	[27.2]	723	[47.1]
CD8⁺	1067↑	[26.1]	708↑	[29.8]	538↑	[34.1]	621↑	[32.0]	831↑	[30.7]	488	[29.8]
α/β⁺-DNT	198↑	[7.3]	117↑	[5.9]	17↑	[0.8]	13↑	[0.5]	66↑	[3.5]	7	[0.5]
γ/δ⁺-DNT	93↑	[2.6]	47↑	[1.5]	33↑	[1.9]	32↑	[1.7]	53↑	[1.9]	18	[1.1]
CD3⁺/HLA-DR⁺	705↑	[21.7]	522↑	[20.2]	201	[11.6]	187	[9.3]	374↑	[15.2]	146	[8.8]
CD3⁺/CD25⁺	270↓	[7.4]	378	[17.3]	411	[24.8]	447	[25.4]	211↓	[9.2]	425	[27.6]
CD8⁺/CD57⁺	444↑	[11.3]	291↑	[11.9]	206	[12.4]	246	[12.0]	297↑	[11.3]	206	[12.5]
B cells
CD20⁺	656↑	[20.8]	295↑	[13.3]	148	[9.2]	235↑	[11.6]	436↑	[14.5]	148	[9.8]
CD5⁺/CD20⁺	526↑	[13.0]	190↑	[6.5]	70	[4.3]	114↑	[5.6]	339↑	[10.6]	56	[3.3]
NK cells
CD3⁻CD16⁺ and/or 56⁺	225	[7.6]	224	[10.1]	209	[11.2]	219	[9.7]	229	[10.5]	212	[15]

Lymphocyte subset	Proband Ia (n = 31)		M⁺/A⁺ (n = 28)		M⁺/A^⁻ (n = 42)		M⁻/A⁻ (n = 65)		Proband II/III (n = 11)		HC (n = 40)
T cells
CD3⁺	*2239^↑**	[70.9^†]	1768↑	[74.1]	1159	[76.7]	1487↑	[76.1]	2138↑	[71.5]	1105	[72.2]
CD4⁺	824	[27.5]	712	[34.3]	654	[43.2]	841	[44.6]	800	[27.2]	723	[47.1]
CD8⁺	1067↑	[26.1]	708↑	[29.8]	538↑	[34.1]	621↑	[32.0]	831↑	[30.7]	488	[29.8]
α/β⁺-DNT	198↑	[7.3]	117↑	[5.9]	17↑	[0.8]	13↑	[0.5]	66↑	[3.5]	7	[0.5]
γ/δ⁺-DNT	93↑	[2.6]	47↑	[1.5]	33↑	[1.9]	32↑	[1.7]	53↑	[1.9]	18	[1.1]
CD3⁺/HLA-DR⁺	705↑	[21.7]	522↑	[20.2]	201	[11.6]	187	[9.3]	374↑	[15.2]	146	[8.8]
CD3⁺/CD25⁺	270↓	[7.4]	378	[17.3]	411	[24.8]	447	[25.4]	211↓	[9.2]	425	[27.6]
CD8⁺/CD57⁺	444↑	[11.3]	291↑	[11.9]	206	[12.4]	246	[12.0]	297↑	[11.3]	206	[12.5]
B cells
CD20⁺	656↑	[20.8]	295↑	[13.3]	148	[9.2]	235↑	[11.6]	436↑	[14.5]	148	[9.8]
CD5⁺/CD20⁺	526↑	[13.0]	190↑	[6.5]	70	[4.3]	114↑	[5.6]	339↑	[10.6]	56	[3.3]
NK cells
CD3⁻CD16⁺ and/or 56⁺	225	[7.6]	224	[10.1]	209	[11.2]	219	[9.7]	229	[10.5]	212	[15]

Bold indicates statistically significant change compared to the HC group.

↑Absolute number higher than HC group.

↓Absolute number lower than HC group.

Median number of cells/μL.

Median percentage of lymphocytes.