Markers of thrombin generation and fibrinolysis in patients with sickle cell disease
| Marker . | Controls (N = 11) . | SC genotype (N = 15) . | SS genotype (N = 25) . |
|---|---|---|---|
| F1.2 (nM) | 0.57 ± 0.21 | 0.87 ± 0.26* | 1.30 ± 0.53* |
| TAT (ng/mL) | 1.6 ± 0.71 | 4.00 ± 4.44* | 5.54 ± 4.89* |
| D-dimer (μg/mL) | 0.05 ± 0.03 | 0.05 ± 0.04 | 0.17 ± 0.20* |
| PAP (μg/mL) | 0.42 ± 0.14 | 0.33 ± 0.22 | 0.49 ± 0.34 |
| tPA (ng/mL) | 3.98 ± 1.55 | 8.27 ± 6.96* | 6.25 ± 3.11 |
| PAI-1 (ng/mL) | 17.8 ± 9.8 | 21.8 ± 13.3 | 24.8 ± 17.7 |
| Marker . | Controls (N = 11) . | SC genotype (N = 15) . | SS genotype (N = 25) . |
|---|---|---|---|
| F1.2 (nM) | 0.57 ± 0.21 | 0.87 ± 0.26* | 1.30 ± 0.53* |
| TAT (ng/mL) | 1.6 ± 0.71 | 4.00 ± 4.44* | 5.54 ± 4.89* |
| D-dimer (μg/mL) | 0.05 ± 0.03 | 0.05 ± 0.04 | 0.17 ± 0.20* |
| PAP (μg/mL) | 0.42 ± 0.14 | 0.33 ± 0.22 | 0.49 ± 0.34 |
| tPA (ng/mL) | 3.98 ± 1.55 | 8.27 ± 6.96* | 6.25 ± 3.11 |
| PAI-1 (ng/mL) | 17.8 ± 9.8 | 21.8 ± 13.3 | 24.8 ± 17.7 |
TAT indicates thrombin-antithrombin; PAP, plasmin-antiplasmin; tPA, tissue plasminogen activator; PAI-1, plasminogen activator inhibitor-1.
Plasma levels of markers of thrombin generation (F1.2 and TAT) and fibrinolysis (D-dimer, PAP, tPA, and PAI-1) were assessed by using commercially available enzyme-linked immunosorbent assay kits. Values presented are the means ± SD.
Marker levels were significantly different from controls atP < .05 to P < .0001.