Relationships between the levels of individual hemostatic markers and presence of phosphatidylserine-positive erythrocytes and platelets in patients with sickle cell disease
| Marker . | Red cell . | Platelet . | ||
|---|---|---|---|---|
| R . | P . | R . | P . | |
| F1.2 | .521 | < .0002 | −.125 | > .35 |
| TAT | .244 | > .09 | −.080 | > .55 |
| D-dimer | .629 | < .000002 | −.087 | > .55 |
| PAP | .372 | < .01 | .015 | > .90 |
| tPA | .028 | > .85 | .045 | > .75 |
| PAI-1 | .241 | > .09 | .189 | > .15 |
| Marker . | Red cell . | Platelet . | ||
|---|---|---|---|---|
| R . | P . | R . | P . | |
| F1.2 | .521 | < .0002 | −.125 | > .35 |
| TAT | .244 | > .09 | −.080 | > .55 |
| D-dimer | .629 | < .000002 | −.087 | > .55 |
| PAP | .372 | < .01 | .015 | > .90 |
| tPA | .028 | > .85 | .045 | > .75 |
| PAI-1 | .241 | > .09 | .189 | > .15 |
TAT indicates thrombin-antithrombin; PAP, plasmin-antiplasmin; tPA, tissue plasminogen activator, PAI-1, plasminogen activator inhibitor-1.
Plasma levels of hemostatic markers were evaluated by using commercially available enzyme-linked immunosorbent assay kits, and circulating levels of phosphatidylserine-positive erythrocytes and platelets were assessed by using annexin V by flow cytometry. Values presented for the R and P values were obtained by using the Pearson test on log-transformed data. Similar results were obtained by using the Spearman test on rank-transformed data.