The effects of MIP-1α and AOP-RANTES on percentage CFU-A colony formation by wild-type and receptor null bone marrow
| Receptor status . | 100 ng/mL MIP-1α . | 100 ng/mL MIP-1α + AOP-RANTES, 500 ng/mL . |
|---|---|---|
| Wild type | 16.7 ± 15.2 | 16.7 ± 15.2 |
| CCR1−/− | 15.9 ± 24.9 | 9.1 ± 14.8 |
| CCR3−/− | 37.0 ± 18.2 | 19.6 ± 20.9 |
| CCR5−/− | 23.3 ± 9.1 | 24.4 ± 4.7 |
| D6−/− | 18.8 ± 17.1 | 21.9 ± 21.0 |
| Receptor status . | 100 ng/mL MIP-1α . | 100 ng/mL MIP-1α + AOP-RANTES, 500 ng/mL . |
|---|---|---|
| Wild type | 16.7 ± 15.2 | 16.7 ± 15.2 |
| CCR1−/− | 15.9 ± 24.9 | 9.1 ± 14.8 |
| CCR3−/− | 37.0 ± 18.2 | 19.6 ± 20.9 |
| CCR5−/− | 23.3 ± 9.1 | 24.4 ± 4.7 |
| D6−/− | 18.8 ± 17.1 | 21.9 ± 21.0 |
Results are expressed as the mean percentage (± SD) of colonies generated in the presence of chemokine compared with control plates. Each result is representative of at least 5 independent experiments using bone marrow from individual mice. MIP indicates macrophage inflammatory protein.