Table 1. Clinical, cytogenetic, and... | American Society of Hematology

Table 1.

Clinical, cytogenetic, and molecular findings in patients with the M4/M5 and non-M4/M5 subtypes

FAB classification	M4/M5	non-M4/M5	P
No. of patients	23	12
Gender
Boys	16	6	.442^*
Girls	7	6
Age
Under 6 mo	10	2	.226^*
6 mo or older	13	10
WBC
Less than 10 000/μL	1	2	.073^†
10 000-49 999/μL	8	6
50 000-99 999/μL	3	3
More than 100 000/μL	11	1
Cytogenetics			< .001^†
11q23 translocations	13	0
inv(16)	3	0
Others	3	12
Normal karyotype	4	0
MLLrearrangement			< .001^*
Positive	16^‡	1^1-153
Negative	7	11

FAB classification	M4/M5	non-M4/M5	P
No. of patients	23	12
Gender
Boys	16	6	.442^*
Girls	7	6
Age
Under 6 mo	10	2	.226^*
6 mo or older	13	10
WBC
Less than 10 000/μL	1	2	.073^†
10 000-49 999/μL	8	6
50 000-99 999/μL	3	3
More than 100 000/μL	11	1
Cytogenetics			< .001^†
11q23 translocations	13	0
inv(16)	3	0
Others	3	12
Normal karyotype	4	0
MLLrearrangement			< .001^*
Positive	16^‡	1^1-153
Negative	7	11

P value estimated by the χ² test.

P value estimated by the Fisher exact test.

Two patients with normal karyotypes and 1 with del(11)(q23) showed positive MLL rearrangements.

One patient with positive MLL rearrangements was classified as the M6 subtype with add(3), der(11),-15,-19, add(21).