Table 2. Summary of the characteristics... | American Society of Hematology

Table 2.

Summary of the characteristics of mouse and human DC subsets

Mouse	Human
Myeloid CD11c⁺CD11b⁺(CD8α⁻) induce strong MLR. Primarily T-cell stimulatory function.	Myeloid DC1 major IL-12–producing DCs, CD11c⁺IL3R⁻, induce strong MLR. Primarily T-cell stimulatory function.
Lymphoid CD11c⁺CD11b⁻(CD8α⁺) can express Fas ligand, produce high amounts of IL-12, and induce weak MLR. Primarily T-cell regulatory function.
Plasmacytoid CD11c⁺CD11b⁻CD8α⁻B220⁺Thy1.2⁺, but low expression of IL-3R Major type I IFN–producing DCs, induce weak MLR and differentiate into DCs upon culture with CD40 antibodies and IL3. Primarily T-cell regulatory function?	Plasmacytoid DC2 major type I IFN–producing cells, CD11c⁻IL3R+CD45R⁺CD4⁺, induce strong MLR and mature into DCs with Th2-stimulating capacity on culture with CD40 antibodies and IL3. T-cell stimulatory and regulatory functions.

Mouse	Human
Myeloid CD11c⁺CD11b⁺(CD8α⁻) induce strong MLR. Primarily T-cell stimulatory function.	Myeloid DC1 major IL-12–producing DCs, CD11c⁺IL3R⁻, induce strong MLR. Primarily T-cell stimulatory function.
Lymphoid CD11c⁺CD11b⁻(CD8α⁺) can express Fas ligand, produce high amounts of IL-12, and induce weak MLR. Primarily T-cell regulatory function.
Plasmacytoid CD11c⁺CD11b⁻CD8α⁻B220⁺Thy1.2⁺, but low expression of IL-3R Major type I IFN–producing DCs, induce weak MLR and differentiate into DCs upon culture with CD40 antibodies and IL3. Primarily T-cell regulatory function?	Plasmacytoid DC2 major type I IFN–producing cells, CD11c⁻IL3R+CD45R⁺CD4⁺, induce strong MLR and mature into DCs with Th2-stimulating capacity on culture with CD40 antibodies and IL3. T-cell stimulatory and regulatory functions.