Table 2. Incidence of 6-TG–resistant... | American Society of Hematology

Table 2.

Incidence of 6-TG–resistant T-cell colonies

	In the absence of 6-TG			In the presence of 6-TG			(b)/(a)^* (/10⁷)
	Plates	Colonies (±SD) × 10²	Colonies per plate (a) × 10²	Plates	Colonies (±SD)	Colonies per plate (b)	(b)/(a)^* (/10⁷)
Patients
2^†	4	200 ± 120	50	15.3	0.3 ± 0.5	0.020	40
3	4	185 ± 81	46	10.7	0.3 ± 0.5	0.028	61
4	4	347 ± 140	87	5.3	0.3 ± 1.0	0.057	66
6	4	47 ± 17	12	16.0	0.7 ± 1.0	0.044	367
7	4	298 ± 116	75	18.3	1.7 ± 1.4	0.093	124
9	4	436 ± 180	109	16.8	2.0 ± 1.7	0.119	109
11	4	451	113	16	1	0.063	56
12	4	165 ± 95	41	13.3	2.0 ± 1.0	0.150	366
AT	4	362	90	76	3	0.039	43
Healthy donors^‡
1	4	584 ± 201	146	133.7	0.3 ± 0.6	0.002	1
2^†	4	375 ± 63	94	66.0	1.0 ± 0.6	0.015	16
3	4	459 ± 50	114	106.7	0.3 ± 0.6	0.003	3

	In the absence of 6-TG			In the presence of 6-TG			(b)/(a)^* (/10⁷)
	Plates	Colonies (±SD) × 10²	Colonies per plate (a) × 10²	Plates	Colonies (±SD)	Colonies per plate (b)	(b)/(a)^* (/10⁷)
Patients
2^†	4	200 ± 120	50	15.3	0.3 ± 0.5	0.020	40
3	4	185 ± 81	46	10.7	0.3 ± 0.5	0.028	61
4	4	347 ± 140	87	5.3	0.3 ± 1.0	0.057	66
6	4	47 ± 17	12	16.0	0.7 ± 1.0	0.044	367
7	4	298 ± 116	75	18.3	1.7 ± 1.4	0.093	124
9	4	436 ± 180	109	16.8	2.0 ± 1.7	0.119	109
11	4	451	113	16	1	0.063	56
12	4	165 ± 95	41	13.3	2.0 ± 1.0	0.150	366
AT	4	362	90	76	3	0.039	43
Healthy donors^‡
1	4	584 ± 201	146	133.7	0.3 ± 0.6	0.002	1
2^†	4	375 ± 63	94	66.0	1.0 ± 0.6	0.015	16
3	4	459 ± 50	114	106.7	0.3 ± 0.6	0.003	3

Each value represents the mean of 3 independent experiments, except the patients with PNH (no. 11) and AT, who were analyzed once.

Pairwise difference between patients with PNH and healthy donors was significant (P < .02, Mann-Whitney test32).

Cigarette smokers.

1, 26-year-old female; 2 and 3, 40- and 69-year-old males.