Table 1.

Main morphologic changes detected on bone marrow biopsy of patients before and during STI571 therapy

PatientsCellularityMegakaryopoiesisFibrosis
123123123
Group 1          
 1 SB ↑↑↑ ↑ ↑↑ 
 2 PM ↑↑↑ ↑ 
 3 ZH ↑↑↑ ↑ ↑↑ ↑ 
 4 UP ↑↑↑ ↑↑ 
 5 SJ ↑↑ ↑ ↑ 
 6 PF ↑ 0  
 7 PE ↑ ↑ 0  
 8 HJ ↑↑↑ ↑ ↑ ↑ 0  
 9 HaJ ↑↑↑ ↑ ↑ 0  
Group 2          
 1 HL ↑↑↑ ↑↑ ↑↑ ↑↑↑ 
 2 UB ↑↑↑ ↑ ↑↑↑ ↑↑ ↑ 
 3 WH ↑↑↑ ↑↑ ↓ ↑ 
 4 HR ↑↑ ↑ ↑ 
 5 ER ↑↑↑ ↑ ↑ ↑↑ ↑ 
 6 WA ↑↑↑ ↑↑ 
 7 DA ↑↑↑ ↑ ↑ 
 8 KG ↑↑↑ ↑↑↑ ↑↑ ↑↑ 
Group 3          
 1 PH ↑↑↑ ↑↑↑ ↑↑ ↓↓ ↓↓ ↓ 
 2 WF ↑↑↑ ↑↑↑ 
 3 FM ↑↑↑ ↑ ↑↑ ↑↑ ↑ 
 4 TJ ↑↑↑ ↑ ↑ ↓↓ 
 5 LK ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↓ 
 6 GR ↑↑↑ ↑↑ ↑↑ ↑ 
PatientsCellularityMegakaryopoiesisFibrosis
123123123
Group 1          
 1 SB ↑↑↑ ↑ ↑↑ 
 2 PM ↑↑↑ ↑ 
 3 ZH ↑↑↑ ↑ ↑↑ ↑ 
 4 UP ↑↑↑ ↑↑ 
 5 SJ ↑↑ ↑ ↑ 
 6 PF ↑ 0  
 7 PE ↑ ↑ 0  
 8 HJ ↑↑↑ ↑ ↑ ↑ 0  
 9 HaJ ↑↑↑ ↑ ↑ 0  
Group 2          
 1 HL ↑↑↑ ↑↑ ↑↑ ↑↑↑ 
 2 UB ↑↑↑ ↑ ↑↑↑ ↑↑ ↑ 
 3 WH ↑↑↑ ↑↑ ↓ ↑ 
 4 HR ↑↑ ↑ ↑ 
 5 ER ↑↑↑ ↑ ↑ ↑↑ ↑ 
 6 WA ↑↑↑ ↑↑ 
 7 DA ↑↑↑ ↑ ↑ 
 8 KG ↑↑↑ ↑↑↑ ↑↑ ↑↑ 
Group 3          
 1 PH ↑↑↑ ↑↑↑ ↑↑ ↓↓ ↓↓ ↓ 
 2 WF ↑↑↑ ↑↑↑ 
 3 FM ↑↑↑ ↑ ↑↑ ↑↑ ↑ 
 4 TJ ↑↑↑ ↑ ↑ ↓↓ 
 5 LK ↑↑↑ ↑↑↑ ↑↑↑ ↓↓ ↓ 
 6 GR ↑↑↑ ↑↑ ↑↑ ↑ 

1 indicates bone marrow biopsy findings before STI571 treatment; 2, bone marrow biopsy findings after 6 weeks STI571 treatment; 3, bone marrow biopsy findings after 3-month STI571 treatment; ↑↑↑, highly increased; ↑↑, moderately increased; ↑, slightly increased; ↓↓↓, highly decreased; ↓↓, moderately decreased; ↓, slightly decreased; and N, normal.

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