Main morphologic changes detected on bone marrow biopsy of patients before and during STI571 therapy
Patients . | Cellularity . | Megakaryopoiesis . | Fibrosis . | ||||||
---|---|---|---|---|---|---|---|---|---|
1 . | 2 . | 3 . | 1 . | 2 . | 3 . | 1 . | 2 . | 3 . | |
Group 1 | |||||||||
1 SB | ↑↑↑ | ↑ | N | ↑↑ | N | N | 1 | 1 | 0 |
2 PM | ↑↑↑ | N | N | ↑ | N | N | 1 | 0 | 0 |
3 ZH | ↑↑↑ | ↑ | N | ↑↑ | ↑ | N | 3 | 1 | 0 |
4 UP | ↑↑↑ | N | N | ↑↑ | N | N | 1 | 0 | 0 |
5 SJ | ↑↑ | N | N | ↑ | N | ↑ | 1 | 0 | 0 |
6 PF | ↑ | N | N | N | N | N | 0 | 0 | 0 |
7 PE | ↑ | N | N | ↑ | N | N | 1 | 0 | 0 |
8 HJ | ↑↑↑ | ↑ | N | ↑ | ↑ | N | 0 | 0 | 0 |
9 HaJ | ↑↑↑ | ↑ | N | ↑ | N | N | 1 | 0 | 0 |
Group 2 | |||||||||
1 HL | ↑↑↑ | N | ↑↑ | ↑↑ | N | ↑↑↑ | 2 | 1 | 1 |
2 UB | ↑↑↑ | ↑ | ↑↑↑ | ↑↑ | N | ↑ | 2 | 1 | 1 |
3 WH | ↑↑↑ | ↑↑ | N | ↓ | ↑ | N | 2 | 0 | 0 |
4 HR | ↑↑ | N | ↑ | N | N | ↑ | 1 | 0 | 0 |
5 ER | ↑↑↑ | ↑ | ↑ | ↑↑ | N | ↑ | 2 | 0 | 0 |
6 WA | ↑↑↑ | N | N | ↑↑ | N | N | 2 | 0 | 0 |
7 DA | ↑↑↑ | N | ↑ | ↑ | N | N | 1 | 0 | 0 |
8 KG | ↑↑↑ | ↑↑↑ | N | ↑↑ | ↑↑ | N | 2 | 1 | 0 |
Group 3 | |||||||||
1 PH | ↑↑↑ | ↑↑↑ | ↑↑ | ↓↓ | ↓↓ | ↓ | 4 | 3 | 3 |
2 WF | ↑↑↑ | N | N | ↑↑↑ | N | N | 4 | 3 | 0 |
3 FM | ↑↑↑ | ↑ | ↑↑ | ↑↑ | N | ↑ | 3 | 0 | 0 |
4 TJ | ↑↑↑ | ↑ | ↑ | ↓↓ | N | N | 1 | 1 | 0 |
5 LK | ↑↑↑ | ↑↑↑ | ↑↑↑ | ↓↓ | ↓ | N | 0 | 0 | 0 |
6 GR | ↑↑↑ | ↑↑ | N | ↑↑ | ↑ | N | 2 | 1 | 1 |
Patients . | Cellularity . | Megakaryopoiesis . | Fibrosis . | ||||||
---|---|---|---|---|---|---|---|---|---|
1 . | 2 . | 3 . | 1 . | 2 . | 3 . | 1 . | 2 . | 3 . | |
Group 1 | |||||||||
1 SB | ↑↑↑ | ↑ | N | ↑↑ | N | N | 1 | 1 | 0 |
2 PM | ↑↑↑ | N | N | ↑ | N | N | 1 | 0 | 0 |
3 ZH | ↑↑↑ | ↑ | N | ↑↑ | ↑ | N | 3 | 1 | 0 |
4 UP | ↑↑↑ | N | N | ↑↑ | N | N | 1 | 0 | 0 |
5 SJ | ↑↑ | N | N | ↑ | N | ↑ | 1 | 0 | 0 |
6 PF | ↑ | N | N | N | N | N | 0 | 0 | 0 |
7 PE | ↑ | N | N | ↑ | N | N | 1 | 0 | 0 |
8 HJ | ↑↑↑ | ↑ | N | ↑ | ↑ | N | 0 | 0 | 0 |
9 HaJ | ↑↑↑ | ↑ | N | ↑ | N | N | 1 | 0 | 0 |
Group 2 | |||||||||
1 HL | ↑↑↑ | N | ↑↑ | ↑↑ | N | ↑↑↑ | 2 | 1 | 1 |
2 UB | ↑↑↑ | ↑ | ↑↑↑ | ↑↑ | N | ↑ | 2 | 1 | 1 |
3 WH | ↑↑↑ | ↑↑ | N | ↓ | ↑ | N | 2 | 0 | 0 |
4 HR | ↑↑ | N | ↑ | N | N | ↑ | 1 | 0 | 0 |
5 ER | ↑↑↑ | ↑ | ↑ | ↑↑ | N | ↑ | 2 | 0 | 0 |
6 WA | ↑↑↑ | N | N | ↑↑ | N | N | 2 | 0 | 0 |
7 DA | ↑↑↑ | N | ↑ | ↑ | N | N | 1 | 0 | 0 |
8 KG | ↑↑↑ | ↑↑↑ | N | ↑↑ | ↑↑ | N | 2 | 1 | 0 |
Group 3 | |||||||||
1 PH | ↑↑↑ | ↑↑↑ | ↑↑ | ↓↓ | ↓↓ | ↓ | 4 | 3 | 3 |
2 WF | ↑↑↑ | N | N | ↑↑↑ | N | N | 4 | 3 | 0 |
3 FM | ↑↑↑ | ↑ | ↑↑ | ↑↑ | N | ↑ | 3 | 0 | 0 |
4 TJ | ↑↑↑ | ↑ | ↑ | ↓↓ | N | N | 1 | 1 | 0 |
5 LK | ↑↑↑ | ↑↑↑ | ↑↑↑ | ↓↓ | ↓ | N | 0 | 0 | 0 |
6 GR | ↑↑↑ | ↑↑ | N | ↑↑ | ↑ | N | 2 | 1 | 1 |
1 indicates bone marrow biopsy findings before STI571 treatment; 2, bone marrow biopsy findings after 6 weeks STI571 treatment; 3, bone marrow biopsy findings after 3-month STI571 treatment; ↑↑↑, highly increased; ↑↑, moderately increased; ↑, slightly increased; ↓↓↓, highly decreased; ↓↓, moderately decreased; ↓, slightly decreased; and N, normal.