Summary of the effects of anti-CD44 mAbs A3D8 and H90 on differentiation and survival of NB4, THP-1, HL60, and KG1a cell lines
| . | A3D8 . | H90 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Increase in differentiation antigens' expression . | NBT assay . | Cytologic differentiation . | Increase in differentiation antigens' expression . | NBT assay . | Cytologic differentiation . | |||||
| CD11b . | CD14 . | CD15 . | CD11b . | CD14 . | CD15 . | |||||
| NB4 | + | + | + | + | +/− and apoptosis | + | − | + | − | + (granulocytes) |
| THP-1 | + | + | + | + | + (monocytes) | − | − | − | − | − |
| HL60 | + | + | + | − | + (monocytes) | + | − | + | + | + (granulocytes) |
| KG1a | − | − | − | − | − | − | − | − | − | − |
| KG1a + RA | + | + | + | + | Maturing myeloid cells | + | + | + | + | Maturing myeloid cells |
| . | A3D8 . | H90 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Increase in differentiation antigens' expression . | NBT assay . | Cytologic differentiation . | Increase in differentiation antigens' expression . | NBT assay . | Cytologic differentiation . | |||||
| CD11b . | CD14 . | CD15 . | CD11b . | CD14 . | CD15 . | |||||
| NB4 | + | + | + | + | +/− and apoptosis | + | − | + | − | + (granulocytes) |
| THP-1 | + | + | + | + | + (monocytes) | − | − | − | − | − |
| HL60 | + | + | + | − | + (monocytes) | + | − | + | + | + (granulocytes) |
| KG1a | − | − | − | − | − | − | − | − | − | − |
| KG1a + RA | + | + | + | + | Maturing myeloid cells | + | + | + | + | Maturing myeloid cells |