Table 1. Hemostatic parameters in... | American Society of Hematology

Table 1.

Hemostatic parameters in thalassemia and SCD

	Assay	β-TM	β-TI	α-Thalassemia	SCD
Platelet	Life span	Short	Short
	Aggregation	Impaired	Impaired		Impaired
	Urinary TXA₂	High	High		High
	Circulating platelet aggregates	Present	Present	Present	Present
	CD62, CD63	High	High		High
	PF3	High	High	High
	PF4, β-TG	High	High		High
Vascular endothelium	Thrombomodulin	High	High		High
	ICAM-1	High	High		High
	VCAM-1	High	High		High
	VWF	High	High		High
	E-selectin	High	High		High
	Urinary PGI₂	High	High		High
RBC	Annexin V binding	Increased	Increased		Increased
	Thrombin generation	Increased	Increased		Increased
Coagulation factors	Factor II	Low	Low
	Factors V, VII, X	Normal	Normal
Coagulation inhibitors	Protein C (antigen, activity)	Low	Low		Low
	Protein S (free)	Low	Low		Low
	ATIII	Normal	Low		Normal
	HCII	Low
Thrombin generation	TAT	High	High	High	High
	F_1,2	Normal	High		Normal
	FPA		High		High
	D-dimer		High		High

	Assay	β-TM	β-TI	α-Thalassemia	SCD
Platelet	Life span	Short	Short
	Aggregation	Impaired	Impaired		Impaired
	Urinary TXA₂	High	High		High
	Circulating platelet aggregates	Present	Present	Present	Present
	CD62, CD63	High	High		High
	PF3	High	High	High
	PF4, β-TG	High	High		High
Vascular endothelium	Thrombomodulin	High	High		High
	ICAM-1	High	High		High
	VCAM-1	High	High		High
	VWF	High	High		High
	E-selectin	High	High		High
	Urinary PGI₂	High	High		High
RBC	Annexin V binding	Increased	Increased		Increased
	Thrombin generation	Increased	Increased		Increased
Coagulation factors	Factor II	Low	Low
	Factors V, VII, X	Normal	Normal
Coagulation inhibitors	Protein C (antigen, activity)	Low	Low		Low
	Protein S (free)	Low	Low		Low
	ATIII	Normal	Low		Normal
	HCII	Low
Thrombin generation	TAT	High	High	High	High
	F_1,2	Normal	High		Normal
	FPA		High		High
	D-dimer		High		High

The various assays are detailed in the text.