Molecular abnormalities and subcellular distribution of fusion proteins in ALK-positive lymphomas
| Fusion gene . | Chromosomal abnormality . | Molecular wt of fusion protein (kd) . | Staining pattern of ALK protein . | Staining pattern of NPM (N-terminal) . |
|---|---|---|---|---|
| NPM-ALK | t(2;5)(p23;q35) | 80 | Nuclear and cytoplasmic | Nuclear and cytoplasmic |
| TPM3-ALK | t(1;2)(q21;p23) | 104 | Cytoplasmic | Nuclear |
| TPM4-ALK | t(2;19)(p23;p13.3) | 100 | Cytoplasmic | Nuclear |
| TFG-ALK | t(2;3)(p23;q21) | 85 and 97 | Cytoplasmic | Nuclear |
| ATIC-ALK | Inv(2)(p23;q35) | 95 | Cytoplasmic | Nuclear |
| CLTCL-ALK | t(2;22)(p23;q11.2)4-150 | 245 | Cytoplasmic (granular) | Nuclear |
| MSN-ALK | t(X;2)(q11-12;p23)4-150 | 125 | Membrane | Nuclear |
| Fusion gene . | Chromosomal abnormality . | Molecular wt of fusion protein (kd) . | Staining pattern of ALK protein . | Staining pattern of NPM (N-terminal) . |
|---|---|---|---|---|
| NPM-ALK | t(2;5)(p23;q35) | 80 | Nuclear and cytoplasmic | Nuclear and cytoplasmic |
| TPM3-ALK | t(1;2)(q21;p23) | 104 | Cytoplasmic | Nuclear |
| TPM4-ALK | t(2;19)(p23;p13.3) | 100 | Cytoplasmic | Nuclear |
| TFG-ALK | t(2;3)(p23;q21) | 85 and 97 | Cytoplasmic | Nuclear |
| ATIC-ALK | Inv(2)(p23;q35) | 95 | Cytoplasmic | Nuclear |
| CLTCL-ALK | t(2;22)(p23;q11.2)4-150 | 245 | Cytoplasmic (granular) | Nuclear |
| MSN-ALK | t(X;2)(q11-12;p23)4-150 | 125 | Membrane | Nuclear |
ALK indicates anaplastic lymphoma kinase;NPM, nucleophosmin; TPM3 and TPM4,nonmuscle tropomyosin 3 and 4; TFG, TRK-fused gene;ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; CLCTL, clathrin heavy chain-like gene; and MSN, moesin.
Predicted on the basis of molecular studies but not observed cytogenetically in ALK-positive lymphomas.