Relocation of proteins in hematologic neoplasia after hybrid gene formation
| Fusion protein . | Location of wild-type proteins . | New site of fusion protein . |
|---|---|---|
| PML-RARα156,161-164 176-180 | PML: in large nuclear bodies (PML oncogenic domains) | Multiple small intranuclear bodies |
| PLZF-RARα5-150194 195 | PLZF: in 0.3-0.5 μm nuclear bodies5-151 | Multiple small intranuclear bodies5-152 |
| NPM-RARα5-150182 | NPM: in nucleoli | Diffuse pattern throughout nucleus |
| NuMA-RARα5-150192 | NuMA: diffusely distributed in nucleus | Sheetlike aggregates of protein in nucleus |
| BCR-ABL287 297 | ABL: associated with cell-surface membrane and cytoplasm | Nucleus |
| E2A-PBX298 | E2A and PBX: in cytoplasm | Spherical intranuclear bodies |
| NPM-ALK277 | ALK: associated with cell-surface membrane and cytoplasm | Cytoplasm and nucleus (nucleoli) |
| NPM-MLF1262 (B.F., unpublished data, 2001) | MLF1: in cytoplasm | Nucleus |
| CAN-DEK and CAN-SET299 | CAN: associated with nuclear envelope | Nucleus |
| Fusion protein . | Location of wild-type proteins . | New site of fusion protein . |
|---|---|---|
| PML-RARα156,161-164 176-180 | PML: in large nuclear bodies (PML oncogenic domains) | Multiple small intranuclear bodies |
| PLZF-RARα5-150194 195 | PLZF: in 0.3-0.5 μm nuclear bodies5-151 | Multiple small intranuclear bodies5-152 |
| NPM-RARα5-150182 | NPM: in nucleoli | Diffuse pattern throughout nucleus |
| NuMA-RARα5-150192 | NuMA: diffusely distributed in nucleus | Sheetlike aggregates of protein in nucleus |
| BCR-ABL287 297 | ABL: associated with cell-surface membrane and cytoplasm | Nucleus |
| E2A-PBX298 | E2A and PBX: in cytoplasm | Spherical intranuclear bodies |
| NPM-ALK277 | ALK: associated with cell-surface membrane and cytoplasm | Cytoplasm and nucleus (nucleoli) |
| NPM-MLF1262 (B.F., unpublished data, 2001) | MLF1: in cytoplasm | Nucleus |
| CAN-DEK and CAN-SET299 | CAN: associated with nuclear envelope | Nucleus |