Thalidomide doses and response
| Patient no. . | Treatment duration, wk . | Final dose, mg/d . | Response to thalidomide . | Toxicity (WHO grade) . |
|---|---|---|---|---|
| 1 | 40 | 400 | PR | Constipation (2) |
| 2 | 15 | 400 | No response | Constipation (1) |
| 3 | 19 | 200 | PR | Constipation (2) |
| 4 | 3 | 400 | Withdrawal (early progression) | N/A |
| 5 | 14 | 200 | HI | Constipation (3) |
| 6 | 2 | 200 | Withdrawal (drug intolerance) | Neuropathy (2) |
| 7 | 1 | 200 | Withdrawal (personal decision) | Fatigue (1) |
| 8 | 4 | 400 | Withdrawal (personal decision) | Fatigue (2), rash (2) |
| 9 | 4 | 200 | Withdrawal (early progression) | Fatigue (2) |
| 10 | 7 | 400 | No response | Fatigue (1), constipation (2) |
| 11 | 5 | 200 | PR | Fatigue (1), rash (2), neuropathy (2) |
| 12 | 9 | 400 | No response | Constipation (2) |
| 13 | 8 | 200 | Progression | Fatigue (2), neuropathy (1) |
| 14 | 2 | 200 | Withdrawal (early progression) | Rash (2) |
| 15 | 5 | 200 | Progression | Fatigue (1), constipation (2), rash (1) |
| 16 | 11 | 200 | No response | Fatigue (2) |
| 17 | 7 | 200 | Progression | Fatigue (1), constipation (2) |
| 18 | 3 | 200 | Withdrawal (drug intolerance) | Fatigue (1), neuropathy (2) |
| 19 | 9 | 200 | No response | Fatigue (2) |
| 20 | 8 | 200 | PR | Fatigue (1), constipation (2), rash (1) |
| Patient no. . | Treatment duration, wk . | Final dose, mg/d . | Response to thalidomide . | Toxicity (WHO grade) . |
|---|---|---|---|---|
| 1 | 40 | 400 | PR | Constipation (2) |
| 2 | 15 | 400 | No response | Constipation (1) |
| 3 | 19 | 200 | PR | Constipation (2) |
| 4 | 3 | 400 | Withdrawal (early progression) | N/A |
| 5 | 14 | 200 | HI | Constipation (3) |
| 6 | 2 | 200 | Withdrawal (drug intolerance) | Neuropathy (2) |
| 7 | 1 | 200 | Withdrawal (personal decision) | Fatigue (1) |
| 8 | 4 | 400 | Withdrawal (personal decision) | Fatigue (2), rash (2) |
| 9 | 4 | 200 | Withdrawal (early progression) | Fatigue (2) |
| 10 | 7 | 400 | No response | Fatigue (1), constipation (2) |
| 11 | 5 | 200 | PR | Fatigue (1), rash (2), neuropathy (2) |
| 12 | 9 | 400 | No response | Constipation (2) |
| 13 | 8 | 200 | Progression | Fatigue (2), neuropathy (1) |
| 14 | 2 | 200 | Withdrawal (early progression) | Rash (2) |
| 15 | 5 | 200 | Progression | Fatigue (1), constipation (2), rash (1) |
| 16 | 11 | 200 | No response | Fatigue (2) |
| 17 | 7 | 200 | Progression | Fatigue (1), constipation (2) |
| 18 | 3 | 200 | Withdrawal (drug intolerance) | Fatigue (1), neuropathy (2) |
| 19 | 9 | 200 | No response | Fatigue (2) |
| 20 | 8 | 200 | PR | Fatigue (1), constipation (2), rash (1) |
WHO indicates World Health Organization; PR, partial response; NA, not applicable; and HI, hematologic improvement.