Hematologic variables in adult mice, according to genotype
| Variable . | Genotype . | ||
|---|---|---|---|
| ATF4+/+ . | ATF4+/− . | ATF4−/− . | |
| Hematocrit* | 0.45 ± 0.02 | 0.44 ± .01 | 0.40 ± .01 |
| Hemoglobin, g/L* | 129 ± 6 | 124 ± 4 | 103 ± 5 |
| RBC count, 1012/L* | 8.7 ± 0.3 | 8.5 ± 0.3 | 7.7 ± 0.3 |
| MCH, pg* | 14.4 ± 0.5 | 14.6 ± 0.3 | 13.3 ± 0.2 |
| MCHC, g/L | 302 ± 7 | 292 ± 6 | 290 ± 4 |
| MCV, fL* | 47.9 ± 1.0 | 49.7 ± 0.7 | 45.8 ± 0.8 |
| RDW* | 19.2 ± 0.7 | 19.3 ± 0.4 | 20.6 ± 0.3 |
| Reticulocytes | 0.02 ± 0.003 | 0.03 ± 0.002 | 0.03 ± 0.003 |
| WBC count, 109/L | 7.1 ± 0.7 | 8.8 ± 0.6 | 10.3 ± 1.0 |
| Variable . | Genotype . | ||
|---|---|---|---|
| ATF4+/+ . | ATF4+/− . | ATF4−/− . | |
| Hematocrit* | 0.45 ± 0.02 | 0.44 ± .01 | 0.40 ± .01 |
| Hemoglobin, g/L* | 129 ± 6 | 124 ± 4 | 103 ± 5 |
| RBC count, 1012/L* | 8.7 ± 0.3 | 8.5 ± 0.3 | 7.7 ± 0.3 |
| MCH, pg* | 14.4 ± 0.5 | 14.6 ± 0.3 | 13.3 ± 0.2 |
| MCHC, g/L | 302 ± 7 | 292 ± 6 | 290 ± 4 |
| MCV, fL* | 47.9 ± 1.0 | 49.7 ± 0.7 | 45.8 ± 0.8 |
| RDW* | 19.2 ± 0.7 | 19.3 ± 0.4 | 20.6 ± 0.3 |
| Reticulocytes | 0.02 ± 0.003 | 0.03 ± 0.002 | 0.03 ± 0.003 |
| WBC count, 109/L | 7.1 ± 0.7 | 8.8 ± 0.6 | 10.3 ± 1.0 |
Values are means ± SEM. The numbers of adult mice of each genotype (+/+:+/−:−/−) assayed to determine the hematocrit and reticulocyte values were 22:48:49 and 6:26:18, respectively.
RBC indicates red blood cell; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; RDW, red cell distribution width; and WBC, white blood cell.
Significant difference between ATF4−/− mice and heterozygous controls. There was no significant difference between ATF4+/+ and ATF+/− adults in any assay.