PML-RARα missense mutations identified in relapse, RA-treated APL patients
| Mutation3-150 . | Missense identified . | References . |
|---|---|---|
| Lys207Asn | 1 | This report |
| Arg272Gln | 3 | Imaizumi et al,6 Marasca et al7 and this report |
| Arg276Trp | 2 | Marasca et al7 and Takayama et al45 |
| Gly289Arg | 1 | This report |
| Leu290Val | 1 | Ding et al5 |
| Arg294Trp | 1 | This report |
| Met297Leu | 1 | Imaizumi et al6 |
| Arg394Trp | 1 | Ding et al5 |
| Pro407Ser | 1 | This report |
| Met413Thr | 1 | Ding et al5 |
| Mutation3-150 . | Missense identified . | References . |
|---|---|---|
| Lys207Asn | 1 | This report |
| Arg272Gln | 3 | Imaizumi et al,6 Marasca et al7 and this report |
| Arg276Trp | 2 | Marasca et al7 and Takayama et al45 |
| Gly289Arg | 1 | This report |
| Leu290Val | 1 | Ding et al5 |
| Arg294Trp | 1 | This report |
| Met297Leu | 1 | Imaizumi et al6 |
| Arg394Trp | 1 | Ding et al5 |
| Pro407Ser | 1 | This report |
| Met413Thr | 1 | Ding et al5 |
RA indicates all-l retinoic acid; APL, acute promyelocytic leukemia.
Nucleotide and amino acid numbers correspond to that for normal RARα1.44