Table 4. Relationship between... | American Society of Hematology

Table 4.

Relationship between proliferation index provided by Ki67 expression and other variables

Variable	N	Median of Ki67 expression (%)	Univariate analysis		Median regression
Variable	N	Median of Ki67 expression (%)	P25-P75 (%)	P	Beta (%)	95% CI (%)	P
p14^ARF
Nonnucleoplasmic	56	77	60 -90
Nucleoplasmic	14	91	86 -95	.002	12	0.9-23.1	.035
IPI
0 to 1	15	85	65 -95
2	14	73	60 -95
3	10	83	70 -95
4 to 5	11	80	70 -90	.955
Histology
Non-Burkitt	58	76	30 -87
Burkitt	12	95	90 -99	< .001	23	11.9-34.1	< .001
p53 expression
Less than 10%	17	60	50 -90
10% to 50%	26	80	70 -90
At least 50%	23	90	75 -95	.022	10	−1.4-21.4	.086
p53 mutation
No	42	80	60 -95
Yes	9	90	85 -90	.226
Hdm2
Less than 10%	18	65	60 -75
10% to 40%	21	87	75 -95
At least 40%	24	86	70 -92	.007	5	−6.2-16.2	.374

Variable	N	Median of Ki67 expression (%)	Univariate analysis		Median regression
Variable	N	Median of Ki67 expression (%)	P25-P75 (%)	P	Beta (%)	95% CI (%)	P
p14^ARF
Nonnucleoplasmic	56	77	60 -90
Nucleoplasmic	14	91	86 -95	.002	12	0.9-23.1	.035
IPI
0 to 1	15	85	65 -95
2	14	73	60 -95
3	10	83	70 -95
4 to 5	11	80	70 -90	.955
Histology
Non-Burkitt	58	76	30 -87
Burkitt	12	95	90 -99	< .001	23	11.9-34.1	< .001
p53 expression
Less than 10%	17	60	50 -90
10% to 50%	26	80	70 -90
At least 50%	23	90	75 -95	.022	10	−1.4-21.4	.086
p53 mutation
No	42	80	60 -95
Yes	9	90	85 -90	.226
Hdm2
Less than 10%	18	65	60 -75
10% to 40%	21	87	75 -95
At least 40%	24	86	70 -92	.007	5	−6.2-16.2	.374

N indicates number of patients; CI, confidence interval; Beta, change in the median value of Ki67 compared with the reference category.