Table 4.

Comparison of clinical and laboratory characteristics of MDS patients responding and not responding to ATRA plus EPO treatment

Responders
(range)
Nonresponders
(range)
P
Median age, y 66  (54-77) 69  (52-78) .319 330 
M/F 6/7 7/7 1.000 000  
MDS duration, mo 22  (12-56) 25  (8-55) .644 601  
Serum EPO 322  (80-1115) 467  (125-1482) .468 262  
Prior RBC transfusion
requirements, U/mo 
2  (0-4) 2.5  (0-4) .507 629  
Hb levels, g/dL 7.9  (6.7-9.3) 8.1  (6.1-9.5) .884 009  
Reticulocytes, × 109/L 22.33  (5.9-80.0) 18.89  (4.86-86.3) .752 408  
ANC, × 109/L 2.4  (0.5-3.7) 1.55  (0.9-4.1) .144 909  
Platelets, × 109/L 104  (32-220) 133.5  (67-298) .528 024  
Cytogenetics,
normal/abnormal 
5/4 7/3 .649 920 
Responders
(range)
Nonresponders
(range)
P
Median age, y 66  (54-77) 69  (52-78) .319 330 
M/F 6/7 7/7 1.000 000  
MDS duration, mo 22  (12-56) 25  (8-55) .644 601  
Serum EPO 322  (80-1115) 467  (125-1482) .468 262  
Prior RBC transfusion
requirements, U/mo 
2  (0-4) 2.5  (0-4) .507 629  
Hb levels, g/dL 7.9  (6.7-9.3) 8.1  (6.1-9.5) .884 009  
Reticulocytes, × 109/L 22.33  (5.9-80.0) 18.89  (4.86-86.3) .752 408  
ANC, × 109/L 2.4  (0.5-3.7) 1.55  (0.9-4.1) .144 909  
Platelets, × 109/L 104  (32-220) 133.5  (67-298) .528 024  
Cytogenetics,
normal/abnormal 
5/4 7/3 .649 920 

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