Intergroup comparison of the levels of coagulation parameters in groups A, B, and C
| . | A (UFH) N = 375 . | B (reviparin bid) N = 388 . | C (reviparin od) N = 374 . | P . | ||
|---|---|---|---|---|---|---|
| A vs B . | A vs C . | B vs C . | ||||
| Baseline | ||||||
| aPTT (s) | 47.8 (41.2, 67.0) | 48.2 (41.0, 62.4) | 47.6 (40.4, 62.1) | .84 | .80 | .97 |
| Anti-factor Xa (U/mL) | 0.09 (0.03, 0.36) | 0.05 (0.00, 0.20) | 0.04 (0.01, 0.22) | < .001 | < .001 | .22 |
| Fibrinogen (g/L) | 3.61 (2.95, 4.63) | 3.58 (2.90, 4.51) | 3.56 (2.87, 4.55) | .37 | .38 | 1.00 |
| AT (% of normal) | 83.0 (69.0, 95.5) | 83.0 (70.0, 93.0) | 83.0 (69.0, 95.0) | .95 | .97 | .95 |
| TAT complexes (ng/mL) | 4.88 (2.98, 9.51) | 5.08 (3.28, 10.2) | 5.43 (3.27, 11.6) | .23 | .10 | .64 |
| Prothrombin F1 + 2 (ng/mL) | 1.64 (0.95, 3.16) | 1.78 (1.04, 3.12) | 1.62 (1.03, 2.76) | .43 | .49 | .11 |
| ETP-ext (nM/min) | 603 (318, 754) | 627 (392, 762) | 639 (485, 752) | .32 | .06 | .28 |
| D-dimer (ng/mL) | 446 (213, 834) | 483 (228, 798) | 428 (203, 900) | .37 | .86 | .54 |
| TFPI level (U/mL) | 144 (102, 218) | 129 (87.5, 189) | 136 (102, 206) | < .001 | .27 | .01 |
| TAFI level (μg/mL) | 5.70 (5.40, 6.00) | 5.70 (5.50, 6.10) | 5.70 (5.40, 6.00) | .43 | .78 | .29 |
| First wk | ||||||
| aPTT (s) | 66.2 (52.9, 88.2) | 63.7 (52.2, 74.8) | 45.1 (40.0, 52.4) | .07 | < .001 | < .001 |
| Antifactor Xa (U/mL) | 0.21 (0.06, 0.48) | 0.40 (0.17, 0.62) | 0.32 (0.13, 0.68) | < .001 | < .001 | .53 |
| Fibrinogen (g/L) | 4.27 (3.50, 5.28) | 4.04 (3.29, 5.08) | 3.70 (3.04, 4.64) | .05 | < .001 | < .001 |
| AT (% of normal) | 72.0 (58.0, 84.0) | 87.0 (76.0, 98.0) | 86.0 (76.0, 96.0) | < .001 | < .001 | .68 |
| TAT complexes (ng/mL) | 3.14 (2.17, 5.24) | 2.70 (2.10, 4.22) | 3.84 (2.77, 7.21) | .02 | < .001 | < .001 |
| Prothrombin F1 + 2 (ng/mL) | 0.96 (0.58, 1.74) | 0.68 (0.44, 1.22) | 1.25 (0.84, 1.96) | < .001 | < .001 | < .001 |
| ETP-ext (nM/min) | 314 (197, 489) | 263 (194, 358) | 631 (469, 743) | < .001 | < .001 | < .001 |
| D-dimer (ng/mL) | 328 (159, 576) | 280 (138, 445) | 287 (145, 525) | .006 | .23 | .16 |
| TFPI level (U/mL) | 128 (86.7, 193) | 136 (98.3, 215) | 160 (113, 251) | .04 | < .001 | < .001 |
| TAFI level (μg/mL) | 5.10 (4.80, 5.40) | 5.00 (4.70, 5.20) | 5.00 (4.30, 5.20) | .007 | < .001 | .002 |
| Third wk | ||||||
| Fibrinogen (g/L) | 3.88 (3.22, 4.66) | 3.83 (3.19, 4.52) | 3.17 (2.63, 3.82) | .25 | < .001 | < .001 |
| TAT complexes (ng/mL) | 2.25 (1.66, 3.49) | 2.11 (1.70, 3.17) | 2.92 (2.11, 4.88) | .21 | < .001 | < .001 |
| Prothrombin F1 + 2 (ng/mL) | 0.45 (0.24, 0.94) | 0.34 (0.20, 0.68) | 1.10 (0.72, 1.63) | < .001 | < .001 | < .001 |
| ETP-ext (nM/min) | 251 (176, 354) | 212 (150, 326) | 591 (440, 710) | .009 | < .001 | < .001 |
| D-dimer (ng/mL) | 110 (46.1, 207) | 70.1 (26.8, 160) | 83.7 (35.1, 178) | < .001 | .08 | .07 |
| TFPI level (U/mL) | 96.7 (78.3, 128) | 108 (79.5, 146) | 139 (107, 231) | .03 | < .001 | < .001 |
| TAFI level (μg/mL) | 5.50 (5.00, 5.80) | 5.40 (5.10, 5.70) | 4.80 (4.30, 5.10) | .06 | < .001 | < .001 |
| . | A (UFH) N = 375 . | B (reviparin bid) N = 388 . | C (reviparin od) N = 374 . | P . | ||
|---|---|---|---|---|---|---|
| A vs B . | A vs C . | B vs C . | ||||
| Baseline | ||||||
| aPTT (s) | 47.8 (41.2, 67.0) | 48.2 (41.0, 62.4) | 47.6 (40.4, 62.1) | .84 | .80 | .97 |
| Anti-factor Xa (U/mL) | 0.09 (0.03, 0.36) | 0.05 (0.00, 0.20) | 0.04 (0.01, 0.22) | < .001 | < .001 | .22 |
| Fibrinogen (g/L) | 3.61 (2.95, 4.63) | 3.58 (2.90, 4.51) | 3.56 (2.87, 4.55) | .37 | .38 | 1.00 |
| AT (% of normal) | 83.0 (69.0, 95.5) | 83.0 (70.0, 93.0) | 83.0 (69.0, 95.0) | .95 | .97 | .95 |
| TAT complexes (ng/mL) | 4.88 (2.98, 9.51) | 5.08 (3.28, 10.2) | 5.43 (3.27, 11.6) | .23 | .10 | .64 |
| Prothrombin F1 + 2 (ng/mL) | 1.64 (0.95, 3.16) | 1.78 (1.04, 3.12) | 1.62 (1.03, 2.76) | .43 | .49 | .11 |
| ETP-ext (nM/min) | 603 (318, 754) | 627 (392, 762) | 639 (485, 752) | .32 | .06 | .28 |
| D-dimer (ng/mL) | 446 (213, 834) | 483 (228, 798) | 428 (203, 900) | .37 | .86 | .54 |
| TFPI level (U/mL) | 144 (102, 218) | 129 (87.5, 189) | 136 (102, 206) | < .001 | .27 | .01 |
| TAFI level (μg/mL) | 5.70 (5.40, 6.00) | 5.70 (5.50, 6.10) | 5.70 (5.40, 6.00) | .43 | .78 | .29 |
| First wk | ||||||
| aPTT (s) | 66.2 (52.9, 88.2) | 63.7 (52.2, 74.8) | 45.1 (40.0, 52.4) | .07 | < .001 | < .001 |
| Antifactor Xa (U/mL) | 0.21 (0.06, 0.48) | 0.40 (0.17, 0.62) | 0.32 (0.13, 0.68) | < .001 | < .001 | .53 |
| Fibrinogen (g/L) | 4.27 (3.50, 5.28) | 4.04 (3.29, 5.08) | 3.70 (3.04, 4.64) | .05 | < .001 | < .001 |
| AT (% of normal) | 72.0 (58.0, 84.0) | 87.0 (76.0, 98.0) | 86.0 (76.0, 96.0) | < .001 | < .001 | .68 |
| TAT complexes (ng/mL) | 3.14 (2.17, 5.24) | 2.70 (2.10, 4.22) | 3.84 (2.77, 7.21) | .02 | < .001 | < .001 |
| Prothrombin F1 + 2 (ng/mL) | 0.96 (0.58, 1.74) | 0.68 (0.44, 1.22) | 1.25 (0.84, 1.96) | < .001 | < .001 | < .001 |
| ETP-ext (nM/min) | 314 (197, 489) | 263 (194, 358) | 631 (469, 743) | < .001 | < .001 | < .001 |
| D-dimer (ng/mL) | 328 (159, 576) | 280 (138, 445) | 287 (145, 525) | .006 | .23 | .16 |
| TFPI level (U/mL) | 128 (86.7, 193) | 136 (98.3, 215) | 160 (113, 251) | .04 | < .001 | < .001 |
| TAFI level (μg/mL) | 5.10 (4.80, 5.40) | 5.00 (4.70, 5.20) | 5.00 (4.30, 5.20) | .007 | < .001 | .002 |
| Third wk | ||||||
| Fibrinogen (g/L) | 3.88 (3.22, 4.66) | 3.83 (3.19, 4.52) | 3.17 (2.63, 3.82) | .25 | < .001 | < .001 |
| TAT complexes (ng/mL) | 2.25 (1.66, 3.49) | 2.11 (1.70, 3.17) | 2.92 (2.11, 4.88) | .21 | < .001 | < .001 |
| Prothrombin F1 + 2 (ng/mL) | 0.45 (0.24, 0.94) | 0.34 (0.20, 0.68) | 1.10 (0.72, 1.63) | < .001 | < .001 | < .001 |
| ETP-ext (nM/min) | 251 (176, 354) | 212 (150, 326) | 591 (440, 710) | .009 | < .001 | < .001 |
| D-dimer (ng/mL) | 110 (46.1, 207) | 70.1 (26.8, 160) | 83.7 (35.1, 178) | < .001 | .08 | .07 |
| TFPI level (U/mL) | 96.7 (78.3, 128) | 108 (79.5, 146) | 139 (107, 231) | .03 | < .001 | < .001 |
| TAFI level (μg/mL) | 5.50 (5.00, 5.80) | 5.40 (5.10, 5.70) | 4.80 (4.30, 5.10) | .06 | < .001 | < .001 |
Median values with first and third quartiles are shown.