Clinical findings
| Patient no. . | Age/sex . | Interval between abciximab exposures, wk . | Platelet level . | Days required to reach 100 × 109/L . | Bleeding symptoms . | Other . | |
|---|---|---|---|---|---|---|---|
| Pretreatment . | Nadir . | ||||||
| 1 | 53/F | 3 | “Normal” | 1 × 109/L | 9 | Petechiae, ecchymoses, gastrointestinal bleeding | Emesis and hypotension 15 minutes after infusion was started, abciximab stopped |
| 2 | 75/F | 15 | 190 × 109/L | 6 × 109/L | > 3 | Petechiae, oozing from venipuncture sites | |
| 3 | 45/F | 2 | “Normal” | 4 × 109/L | < 5 | Petechiae, oozing from venipuncture sites | |
| 4 | 60/M | 3 | “Normal” | 1 × 109/L | 4 | Petechiae | |
| 5 | 63/M | 3 | 142 × 109/L | 1 × 109/L | 5 | Petechiae, oozing from venipuncture sites | Had drop in platelets from 199 × 109/L to 139 × 109/L after first treatment |
| 6 | 48/M | 2 | 139 × 109/L | 6 × 109/L | 6 | Petechiae, ecchymoses | |
| 7 | 41/M | 6 | 239 × 109/L | 5 × 109/L | 4 | Petechiae | |
| 8 | 55/M | 2 | 205 × 109/L | 3 × 109/L | 7 | Petechiae, ecchymoses | |
| 9 | 60/M | 4 | 150 × 109/L | 2 × 109/L | 8 | Petechia, oozing from venipuncture sites, intrapulmonary hemorrhage | Anaphylactic reaction, required mechanical ventilation |
| Patient no. . | Age/sex . | Interval between abciximab exposures, wk . | Platelet level . | Days required to reach 100 × 109/L . | Bleeding symptoms . | Other . | |
|---|---|---|---|---|---|---|---|
| Pretreatment . | Nadir . | ||||||
| 1 | 53/F | 3 | “Normal” | 1 × 109/L | 9 | Petechiae, ecchymoses, gastrointestinal bleeding | Emesis and hypotension 15 minutes after infusion was started, abciximab stopped |
| 2 | 75/F | 15 | 190 × 109/L | 6 × 109/L | > 3 | Petechiae, oozing from venipuncture sites | |
| 3 | 45/F | 2 | “Normal” | 4 × 109/L | < 5 | Petechiae, oozing from venipuncture sites | |
| 4 | 60/M | 3 | “Normal” | 1 × 109/L | 4 | Petechiae | |
| 5 | 63/M | 3 | 142 × 109/L | 1 × 109/L | 5 | Petechiae, oozing from venipuncture sites | Had drop in platelets from 199 × 109/L to 139 × 109/L after first treatment |
| 6 | 48/M | 2 | 139 × 109/L | 6 × 109/L | 6 | Petechiae, ecchymoses | |
| 7 | 41/M | 6 | 239 × 109/L | 5 × 109/L | 4 | Petechiae | |
| 8 | 55/M | 2 | 205 × 109/L | 3 × 109/L | 7 | Petechiae, ecchymoses | |
| 9 | 60/M | 4 | 150 × 109/L | 2 × 109/L | 8 | Petechia, oozing from venipuncture sites, intrapulmonary hemorrhage | Anaphylactic reaction, required mechanical ventilation |